使用可回收的氟代（S）-吡咯烷-硫脲双功能有机催化剂对醛进行对映选择性α-氯化反应。
Enantioselective α-Chlorination of Aldehydes with Recyclable Fluorous (S)-Pyrrolidine-Thiourea Bifunctional Organocatalyst.
作者信息
Wang Liang, Cai Chun, Curran Dennis P, Zhang Wei
机构信息
Chemical Engineering College, Nanjing University of Science & Technology, Nanjing 210094, P. R. China.
出版信息
Synlett. 2010 Jan 1;3(2010):433-436. doi: 10.1055/s-0029-1219198.
Abstract
A novel fluorous (S)-pyrrolidine-thiourea bifunctional organocatalyst is prepared. The catalyst shows good activity and enantioselectivity for direct α-chlorination of aldehydes using N-chlorosuccinimide (NCS) as the chlorine source. It can be recovered from the reaction mixture by fluorous solid-phase extraction with excellent purity for direct reuse.
摘要
制备了一种新型的含氟（S）-吡咯烷-硫脲双功能有机催化剂。该催化剂以N-氯代琥珀酰亚胺（NCS）为氯源，对醛的直接α-氯化反应表现出良好的活性和对映选择性。它可以通过含氟固相萃取从反应混合物中回收，纯度极高，可直接重复使用。
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