Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan.
Molecules. 2010 Nov 15;15(11):8327-48. doi: 10.3390/molecules15118327.
The synthesis and properties of multifunctional thioureas bearing a variety of functional groups at a position remote from the thiourea moiety are described. A 1,5-disubstituted triazole tether connected with a thiourea and another functional group was synthesized via ruthenium catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as asymmetric catalysts and probes for the mechanistic elucidation of the course of the Michael reaction of an α,ß-unsaturated imide.
描述了在远离硫脲部分的位置带有各种官能团的多功能硫脲的合成和性质。通过钌催化的 Huisgen 环加成反应合成了连接硫脲和另一个官能团的 1,5-二取代三唑键。我们展示了合成硫脲作为不对称催化剂和探针在阐明α,β-不饱和亚胺迈克尔反应过程中的应用。
