围产期双酚 A 暴露于 C57B6/129svj 雄性小鼠：成年后潜在的细胞因子/趋化因子产生改变。
Perinatal bisphenol A exposure in C57B6/129svj male mice: potential altered cytokine/chemokine production in adulthood.
机构信息
Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA.
出版信息
Int J Environ Res Public Health. 2010 Jul;7(7):2845-52. doi: 10.3390/ijerph7072845. Epub 2010 Jul 12.
Abstract
Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T(H)1 up-regulation more than T(H)2, and with skewing toward T(H)17 responses.
摘要
受孕老鼠（n=3）从妊娠第 9.5 天至哺乳期结束，通过腹腔注射暴露于双酚 A 下。雄性后代在 20 周龄时评估细胞因子的产生情况。一只受孕对照老鼠未产生雄性，因此排除了统计分析。然而，成年 BPA 后代中出现了细胞因子反复变化的情况。血清中 21 种基础细胞因子水平中有 16 种出现数值增加。ConA 刺激的脾细胞中 21 种细胞因子中有 17 种出现数值增加，LPS 刺激的脾细胞中 21 种细胞因子中有 18 种增加。细胞因子谱表现为 T(H)1 上调多于 T(H)2，并且偏向于 T(H)17 反应。
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