Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Hospital of the Ludwig-Maximilians-University Munich, Ziemssenstrasse 1, 80336 Munich, Germany.
BMC Pulm Med. 2010 Aug 18;10:43. doi: 10.1186/1471-2466-10-43.
Asthma in children is an emerging public health problem in South America. So far, research in this part of the world is limited. This paper presents the methodology and description of the data acquisition of an asthma case-control study conducted in the Central South of Chile.
METHODS/DESIGN: A hospital-based case-control study about asthma (188 cases, 294 controls) in children (6-15 years) was carried out in Valdivia, Chile between November 2008 and December 2009. Data on asthma risk factors were collected by computer-assisted personal interview using validated questions from e.g. ISAAC phase II. Data on household dust exposure (endotoxin, allergen analyses), skin prick tests to most common allergens, stool examinations for parasitic infection, and blood samples (total IgE, genetics) were collected. Additionally, 492 randomly chosen blood donors were recruited in order to assess allele frequencies in the population of Valdivia.
Overall 1,173 participants were contacted. Response was 82% among cases and 65% among controls. Atopic sensitization was high (78% among cases, 47% among controls). Cases had a statistically significantly (p < .0001) increased self-reported 12-month prevalence of symptoms of rhinitis (82% vs. 51%) and wheeze (68% vs. 16%). The study is well placed to address current hypotheses about asthma and its correlates in the South American context. Results of this study might help develop novel, innovative and individualized prevention strategies in countries in transition with respect to the South American context.
在南美洲，儿童哮喘是一个新出现的公共卫生问题。迄今为止，该地区的研究有限。本文介绍了在智利中南地区进行的哮喘病例对照研究的数据采集方法和描述。
方法/设计：这是一项在智利瓦尔迪维亚进行的基于医院的哮喘病例对照研究（188 例病例，294 例对照），研究对象为 6-15 岁的儿童。在 2008 年 11 月至 2009 年 12 月期间，通过计算机辅助个人访谈收集哮喘危险因素的数据，使用例如 ISAAC 第二阶段等验证过的问题。收集了家庭灰尘暴露（内毒素、过敏原分析）、对最常见过敏原的皮肤点刺试验、寄生虫感染的粪便检查和血液样本（总 IgE、遗传学）的数据。此外，还招募了 492 名随机选择的献血者，以评估瓦尔迪维亚人群中的等位基因频率。
总共联系了 1173 名参与者。病例组的反应率为 82%，对照组的反应率为 65%。特应性致敏率很高（病例组为 78%，对照组为 47%）。病例组自我报告的 12 个月症状性鼻炎（82%对 51%）和喘息（68%对 16%）患病率显著增加（p <.0001）。该研究很好地解决了当前关于南美的哮喘及其相关性的假设。该研究的结果可能有助于在南美背景下制定新的、创新的和个体化的预防策略。
