Adams D H, Hathaway M, Shaw J, Burnett D, Elias E, Strain A J
Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.
J Immunol. 1991 Jul 15;147(2):609-12.
In addition to its activities as a growth factor, recent studies suggest an immunoregulatory role for transforming growth factor-beta (TGF-beta). In this context we have demonstrated that TGF-beta is a potent chemotactic factor in vitro for human T lymphocytes at a concentration of 40 fM and for monocytes at a concentration of 0.4 fM but that it has no chemotactic activity for neutrophils. Furthermore, using an assay of lymphocyte subset chemotaxis we have been able to show that TGF-beta can induce migration of both CD4+ and CD8+ T lymphocytes in vitro. This study provides further evidence that TGF-beta acts as a cytokine, being able to attract T lymphocytes and monocytes to sites of inflammation. Its role in the pathogenesis of inflammatory reactions is likely to be complex.
除了作为一种生长因子发挥作用外，最近的研究表明转化生长因子-β（TGF-β）具有免疫调节作用。在这种情况下，我们已经证明，TGF-β在体外对人T淋巴细胞是一种有效的趋化因子，浓度为40飞摩尔，对单核细胞是一种有效的趋化因子，浓度为0.4飞摩尔，但对中性粒细胞没有趋化活性。此外，通过淋巴细胞亚群趋化分析，我们能够证明TGF-β在体外可诱导CD4+和CD8+ T淋巴细胞迁移。这项研究进一步证明TGF-β作为一种细胞因子，能够将T淋巴细胞和单核细胞吸引到炎症部位。其在炎症反应发病机制中的作用可能很复杂。
