内吞凹陷中诱导的域形成、脂质分选和断裂。
Induced domain formation in endocytic invagination, lipid sorting, and scission.
机构信息
Institut Curie, Centre de Recherche, Traffic, Signaling, and Delivery Laboratory, 75248 Paris Cedex 05, France.
出版信息
Cell. 2010 Aug 20;142(4):507-10. doi: 10.1016/j.cell.2010.08.007.
PMID:20723749
Abstract
Lipid segregation occurs in biological membranes, but how this plays into cellular processes like endocytosis has been unclear. Here, we discuss how the active or passive induction of lipid-protein domain formation in membranes can alter membrane mechanics and thus affect processes such as the generation of curvature, the scission of buds and tubules, and lipid sorting.
摘要
脂质分离发生在生物膜中，但这在胞吞等细胞过程中是如何发挥作用的还不清楚。在这里，我们讨论了如何主动或被动诱导膜中脂质-蛋白质域的形成，从而改变膜力学，进而影响曲率的产生、芽和小管的断裂以及脂质分选等过程。
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