抗逆转录病毒疗法作为 HIV 预防：现状与展望。
Antiretroviral therapy as HIV prevention: status and prospects.
机构信息
Alpert Medical School, Brown University, Providence, RI, USA.
出版信息
Am J Public Health. 2010 Oct;100(10):1867-76. doi: 10.2105/AJPH.2009.184796. Epub 2010 Aug 19.
Abstract
As antiretroviral treatment of HIV infection has become increasingly accessible, attention has focused on whether these drugs can used for prevention because of increased tolerability of newer medications, decreased cost, and the limitations of other approaches. We review the status of antiretroviral HIV prevention, including chemoprophylaxis, as well as the effects of treatment of infected individuals on prevention. It is possible that the life-saving agents that have transformed the natural history of AIDS can be a critical component of HIV prevention efforts, but their ultimate role in affecting HIV transmission dynamics remains to be defined.
摘要
随着抗逆转录病毒治疗艾滋病感染变得越来越容易获得，人们的注意力集中在这些药物是否可以用于预防，因为新药物的耐受性增加，成本降低，以及其他方法的局限性。我们回顾了抗逆转录病毒艾滋病预防的现状，包括化学预防，以及治疗感染个体对预防的影响。这些挽救生命的药物已经改变了艾滋病的自然史，它们可能成为艾滋病预防工作的重要组成部分，但它们在影响艾滋病传播动态方面的最终作用仍有待确定。
相似文献
1
Antiretroviral therapy as HIV prevention: status and prospects.抗逆转录病毒疗法作为 HIV 预防：现状与展望。
Am J Public Health. 2010 Oct;100(10):1867-76. doi: 10.2105/AJPH.2009.184796. Epub 2010 Aug 19.
2
Further escalation of the global HIV/AIDS epidemic in 2005 but one million patients on antiretroviral therapy.2005年全球艾滋病毒/艾滋病疫情进一步升级，但有100万患者接受抗逆转录病毒治疗。
Euro Surveill. 2005 Nov 24;10(11):E051124.2. doi: 10.2807/esw.10.47.02838-en.
3
Antiretroviral Medications for the Prevention of HIV Infection: A Clinical Approach to Preexposure Prophylaxis, Postexposure Prophylaxis, and Treatment as Prevention.抗逆转录病毒药物预防 HIV 感染：暴露前预防、暴露后预防和治疗作为预防的临床方法。
Infect Dis Clin North Am. 2019 Sep;33(3):629-646. doi: 10.1016/j.idc.2019.04.002. Epub 2019 Jun 22.
4
[Antiretroviral drugs-based HIV prevention methods: what impact on the HIV epidemic?].[基于抗逆转录病毒药物的艾滋病预防方法：对艾滋病流行有何影响？]
Med Sci (Paris). 2013 Apr;29(4):373-82. doi: 10.1051/medsci/2013294010. Epub 2013 Apr 26.
5
Pre-exposure chemoprophylaxis (PREP) as an HIV prevention strategy.暴露前化学预防（PREP）作为一种预防艾滋病病毒的策略。
J Int Assoc Physicians AIDS Care (Chic). 2003 Jul-Sep;2(3):102-5. doi: 10.1177/154510970300200302.
6
Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel.《成人HIV感染治疗和预防用抗逆转录病毒药物：美国国际抗病毒学会专家组2016年建议》
JAMA. 2016 Jul 12;316(2):191-210. doi: 10.1001/jama.2016.8900.
7
CROI 2014: Advances in antiretroviral therapy.2014年逆转录病毒与机会性感染会议：抗逆转录病毒疗法的进展
Top Antivir Med. 2014 May;22(2):616-31.
8
Prevention of mother-to-child transmission of human immunodeficiency virus among pregnant women using injecting drugs in Ukraine, 2000-10.2000-2010 年乌克兰使用注射吸毒的孕妇预防母婴传播人类免疫缺陷病毒。
Addiction. 2012 Jan;107(1):118-28. doi: 10.1111/j.1360-0443.2011.03609.x. Epub 2011 Oct 12.
9
Does antiretroviral therapy prevent HIV transmission to sexual partners?抗逆转录病毒疗法能否预防HIV传播给性伴侣？
Curr HIV/AIDS Rep. 2007 May;4(2):80-5. doi: 10.1007/s11904-007-0012-y.
10
HIV/AIDS epidemiology, pathogenesis, prevention, and treatment.人类免疫缺陷病毒/获得性免疫缺陷综合征的流行病学、发病机制、预防及治疗
Lancet. 2006 Aug 5;368(9534):489-504. doi: 10.1016/S0140-6736(06)69157-5.
引用本文的文献
1
Review on oral mucosal lesions in HIV patients with and without highly HAART.对接受和未接受高效抗逆转录病毒治疗（HAART）的HIV患者口腔黏膜病变的综述。
Bioinformation. 2024 Nov 30;20(11):1629-1634. doi: 10.6026/9732063002001629. eCollection 2024.
2
The effect of late presentation on HIV related mortality among adolescents in public hospitals of north showa zone Oromiya, Ethiopia; 2022: a retrospective cohort study.埃塞俄比亚北绍阿地区公立医院青少年中晚期就诊对艾滋病毒相关死亡率的影响；2022 年：一项回顾性队列研究。
BMC Infect Dis. 2024 Jun 26;24(1):644. doi: 10.1186/s12879-024-09550-3.
3
Epigenetic Induction of Secondary Metabolites Production in Endophytic Fungi and GC-MS Analysis of Crude Metabolites with Anti-HIV-1 Activity.内生真菌中次生代谢产物产生的表观遗传诱导及具有抗HIV-1活性的粗代谢产物的气相色谱-质谱联用分析
Microorganisms. 2023 May 26;11(6):1404. doi: 10.3390/microorganisms11061404.
4
Substance Use, Highly Active Antiretroviral Therapy, and Liver Enzymes: Evidence From a Cross-Sectional Study of HIV-Infected Adult Patients Without Comorbidities on HAART in the University of Port Harcourt Teaching Hospital.物质使用、高效抗逆转录病毒疗法与肝酶：来自哈科特港大学教学医院接受抗逆转录病毒治疗且无合并症的HIV感染成年患者横断面研究的证据
Front Reprod Health. 2021 Jun 28;3:664080. doi: 10.3389/frph.2021.664080. eCollection 2021.
5
Involvement, Perception, and Understanding as Determinants for Patient-Physician Relationship and Their Association with Adherence: A Questionnaire Survey among People Living with HIV and Antiretroviral Therapy in Austria.参与、感知和理解作为医患关系的决定因素及其与依从性的关联：奥地利艾滋病毒感染者和抗逆转录病毒治疗人群的问卷调查。
Int J Environ Res Public Health. 2022 Aug 19;19(16):10314. doi: 10.3390/ijerph191610314.
6
HIV risk behavior and associated factors among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis.HIV 风险行为及相关因素在埃塞俄比亚 HIV/AIDS 人群中的系统评价和荟萃分析
PLoS One. 2022 Jul 28;17(7):e0269304. doi: 10.1371/journal.pone.0269304. eCollection 2022.
7
Cytokine profiles in highly active antiretroviral treatment non-adherent, adherent and naive HIV-1 infected patients in Western Kenya.在肯尼亚西部，高度活跃的抗逆转录病毒治疗不依从、依从和未感染 HIV-1 的患者的细胞因子谱。
Afr Health Sci. 2021 Dec;21(4):1584-1592. doi: 10.4314/ahs.v21i4.12.
8
A Real-world Evidence-based Management of HIV by Differential Duration HAART Treatment and its Association with Incidence of Oral Lesions.基于真实世界证据的 HIV 差异化时长 HAART 治疗管理及其与口腔病变发生率的关联。
Curr HIV Res. 2022;20(1):91-99. doi: 10.2174/1570162X20666211227154558.
9
Does undernutrition increase the risk of lost to follow-up in adults living with HIV in sub-Saharan Africa? Protocol for a systematic review and meta-analysis.在撒哈拉以南非洲地区，营养不足是否会增加艾滋病毒感染者失访的风险？系统评价和荟萃分析的方案。
BMJ Open. 2021 Dec 14;11(12):e048022. doi: 10.1136/bmjopen-2020-048022.
10
Orofacial lesions associated with long-term highly active antiretroviral therapy among HIV-seropositive adults in Ibadan, Nigeria.尼日利亚伊巴丹地区 HIV 阳性成年人中与长期高效抗逆转录病毒治疗相关的口腔颌面部损害。
Pan Afr Med J. 2021 Apr 15;38:370. doi: 10.11604/pamj.2021.38.370.25322. eCollection 2021.
本文引用的文献
1
Biological Correlates of Sexual Transmission of HIV Practical Consequences and Potential Targets for Public Health : Practical Consequences and Potential Targets for Public Health.HIV性传播的生物学关联：对公共卫生的实际影响及潜在靶点：对公共卫生的实际影响及潜在靶点。
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2002 Mar;45(3):277-85. doi: 10.1007/s00103-001-0367-y.
2
Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis.抗反转录病毒治疗启动后异性 HIV-1 传播：一项前瞻性队列分析。
Lancet. 2010 Jun 12;375(9731):2092-8. doi: 10.1016/S0140-6736(10)60705-2. Epub 2010 May 26.
3
The impact of the President's Emergency Plan for AIDS Relief (PEPfAR) beyond HIV and why it remains essential.总统艾滋病紧急救援计划（PEPfAR）在 HIV 之外的影响，以及为何它仍然至关重要。
Clin Infect Dis. 2010 Jan 15;50(2):272-5. doi: 10.1086/649214.
4
Preexposure antiretroviral prophylaxis attitudes in high-risk Boston area men who report having sex with men: limited knowledge and experience but potential for increased utilization after education.波士顿地区有男男性行为的高危男性对暴露前抗逆转录病毒药物预防的态度：知识和经验有限，但教育后有提高使用率的潜力。
J Acquir Immune Defic Syndr. 2009 Jan 1;50(1):77-83. doi: 10.1097/QAI.0b013e31818d5a27.
5
Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies.每次性行为中异性感染HIV-1的风险：观察性研究的系统评价与荟萃分析
Lancet Infect Dis. 2009 Feb;9(2):118-29. doi: 10.1016/S1473-3099(09)70021-0.
6
Changes in sexual risk behavior among participants in a PrEP HIV prevention trial.一项暴露前预防（PrEP）HIV预防试验参与者的性风险行为变化。
Sex Transm Dis. 2008 Dec;35(12):1002-8.
7
Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model.将普遍自愿艾滋病毒检测与立即进行抗逆转录病毒治疗作为消除艾滋病毒传播的策略：一个数学模型
Lancet. 2009 Jan 3;373(9657):48-57. doi: 10.1016/S0140-6736(08)61697-9. Epub 2008 Nov 27.
8
Disinhibition and risk compensation: scope, definitions, and perspective.去抑制与风险补偿：范围、定义及视角
Sex Transm Dis. 2008 Dec;35(12):1009-10. doi: 10.1097/OLQ.0b013e31818eb752.
9
Circumcision status and risk of HIV and sexually transmitted infections among men who have sex with men: a meta-analysis.男男性行为者的包皮环切状况与艾滋病毒及性传播感染风险：一项荟萃分析。
JAMA. 2008 Oct 8;300(14):1674-84. doi: 10.1001/jama.300.14.1674.
10
Behavioural strategies to reduce HIV transmission: how to make them work better.减少艾滋病毒传播的行为策略：如何使其更有效发挥作用。
Lancet. 2008 Aug 23;372(9639):669-84. doi: 10.1016/S0140-6736(08)60886-7. Epub 2008 Aug 5.
Zotero 插件