Westbury H A, Sinkovic B
Aust Vet J. 1978 Feb;54(2):68-71. doi: 10.1111/j.1751-0813.1978.tb00348.x.
The age of the chicken at the time of infection with infectious avian encephalomyelitis virus (IAEV) and the route of the administration of the virus had a marked effect on the development of the clinical disease. Chickens given the virus by intramuscular, intraperitoneal and oral routes exhibited a decreased susceptibility to development of clinical disease with increasing age. Irrespective of age, chickens were consistently susceptible to intracerebral inoculation of IAEV. Chickens infected with the virus at 1-, 7- and 14-days of age developed lower neutralising antibody titres to IAEV than chickens infected at 21 and 28 days. A relationship between the ability to produce specific neutralising antibody to IAEV and susceptibility to the development of clinical disease is discussed.
感染传染性禽脑脊髓炎病毒（IAEV）时鸡的年龄以及病毒的接种途径对临床疾病的发展有显著影响。通过肌肉内、腹腔内和口服途径接种病毒的鸡，随着年龄增长，临床疾病发展的易感性降低。无论年龄大小，鸡对IAEV脑内接种始终易感。1日龄、7日龄和14日龄感染该病毒的鸡产生的IAEV中和抗体效价比21日龄和28日龄感染的鸡低。文中讨论了产生IAEV特异性中和抗体的能力与临床疾病发展易感性之间的关系。
