Westbury H A, Sinkovic B
Aust Vet J. 1978 Feb;54(2):76-80. doi: 10.1111/j.1751-0813.1978.tb00350.x.
An association was demonstrated between the development of clinical infectious avian encephalomyelitis (IAE), the persistence and titre of infectious avian encephalomyelitis virus (IAEV) in the brain of the chicken, the duration of detectable viraemia and the age of the chicken at the time of infection with the virus. The older the chicken at the time of infection the milder the disease, the lower the virus titre in the brain and the shorter the period of viraemia. IAEV serum neutralising antibody was produced earlier after infection in older chickens, and its detection was associated with decreasing virus titres in the brain and the cessation of detectable viraemia. Treatment of chickens with testosterone in ova, to inhibit the development of antibody synthesis, prevented the onset of age-associated resistance and testosterone treated birds were as susceptible to clinical IAE as baby chickens. The results suggested that the ability to produce IAEV serum neutralising antibody was an important component of age-associated resistance to IAE.
已证实临床传染性禽脑脊髓炎（IAE）的发生、传染性禽脑脊髓炎病毒（IAEV）在鸡脑中的持续存在和滴度、可检测到的病毒血症持续时间与鸡感染该病毒时的年龄之间存在关联。感染时鸡的年龄越大，疾病越轻，脑中病毒滴度越低，病毒血症持续时间越短。IAEV血清中和抗体在老龄鸡感染后产生得更早，其检测与脑中病毒滴度降低和可检测到的病毒血症停止有关。在卵内用睾酮处理鸡以抑制抗体合成的发展，可阻止与年龄相关的抵抗力的产生，经睾酮处理的鸡对临床IAE的易感性与雏鸡相同。结果表明，产生IAEV血清中和抗体的能力是与年龄相关的对IAE抵抗力的重要组成部分。
