Westbury H A, Sinkovic B
Aust Vet J. 1978 Feb;54(2):72-5. doi: 10.1111/j.1751-0813.1978.tb00349.x.
Normal chickens given infectious avian encephalomyelitis virus (IAEV) orally at 1, 7 or 14 days of age developed infectious avian encephalomyelitis (IAE), whereas those dosed with the virus at 21, 28 and 35 days of age did not. Chickens in all of these age groups that had been treated with cyclophosphamide or testosterone developed clinical IAE. Intraperitoneal inoculation of IAEV immunoglobulin at the time of dosing with the virus, or 48 hours later, protected normal and immunosuppressed chickens against the onset of clinical IAE. The titre of IAEV serum neutralising antibody was found to be lower in normal chickens given the virus at 1, 7 and 14 days of age in older chickens. These results suggest a significant role for the humoral immune system in the pathogenesis of IAE and in the development of immunity to the disease.
1日龄、7日龄或14日龄经口给予传染性禽脑脊髓炎病毒（IAEV）的正常鸡会发生传染性禽脑脊髓炎（IAE），而21日龄、28日龄和35日龄给予该病毒的鸡则不会。所有这些年龄组中经环磷酰胺或睾酮处理的鸡都出现了临床IAE。在给予病毒时或48小时后腹腔接种IAEV免疫球蛋白，可保护正常和免疫抑制的鸡不发生临床IAE。发现1日龄、7日龄和14日龄给予病毒的正常鸡的IAEV血清中和抗体效价比大龄鸡低。这些结果表明体液免疫系统在IAE发病机制及对该病的免疫发展中起重要作用。
