Thommen Medical AG, Headquarters, Waldenburg, Switzerland.
J Mater Sci Mater Med. 2010 Oct;21(10):2751-63. doi: 10.1007/s10856-010-4138-x. Epub 2010 Aug 20.
A new strategy to render intrinsically hydrophobic microrough titanium implant surfaces superhydrophilic is reported, which is based on a rapid treatment with diluted aqueous sodium hydroxide solutions. The physicochemical characterization and protein interaction of the resulting superhydrophilic implant surfaces are presented. The superhydrophilicity of alkali treated microrough titanium substrates was mainly attributed to deprotonation and ion exchange processes in combination with a strong enhancement of wettability due to the roughness of the used substrates. Albeit these minor and mostly reversible chemical changes qualitative and quantitative differences between the protein adsorption on untreated and alkali treated microrough titanium substrates were detected. These differences in protein adsorption might account for the enhanced osseointegrative potential of superhydrophilic alkali treated microrough implant surfaces. The presented alkali treatment protocol represents a new clinically applicable route to superhydrophilic microrough titanium substrates by rendering the implant surface superhydrophilic "in situ of implantation".
报道了一种新策略，可将原本疏水性的微粗糙钛植入物表面变为超亲水，该策略基于用稀释的氢氧化钠水溶液进行快速处理。本文介绍了由此产生的超亲水植入物表面的理化特性和蛋白质相互作用。碱处理后的微粗糙钛基底的超亲水性主要归因于去质子化和离子交换过程，再加上使用的基底的粗糙度导致润湿性得到了极大增强。尽管这些化学变化很小且大多是可逆的，但在未经处理和碱处理的微粗糙钛基底上的蛋白质吸附之间检测到了定性和定量的差异。这些蛋白质吸附的差异可能是由于超亲水碱处理的微粗糙植入物表面具有增强的骨整合潜力。所提出的碱处理方案通过使植入物表面超亲水“在植入时原位”提供了一种新的临床适用方法来获得超亲水的微粗糙钛基底。
