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纳米技术在药物输送和组织工程中的应用:从发现到应用。

Nanotechnology in drug delivery and tissue engineering: from discovery to applications.

机构信息

MIT-Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Nano Lett. 2010 Sep 8;10(9):3223-30. doi: 10.1021/nl102184c.

DOI:10.1021/nl102184c
PMID:20726522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2935937/
Abstract

The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities in healthcare. Herein, we discuss two important aspects of nanomedicine, drug delivery and tissue engineering, highlighting the advances we have recently experienced, the challenges we are currently facing, and what we are likely to witness in the near future.

摘要

纳米技术在医学中的应用,被称为纳米医学,为医疗保健领域带来了众多令人兴奋的可能性。在此,我们讨论纳米医学的两个重要方面,药物输送和组织工程,重点介绍我们最近所取得的进展、当前所面临的挑战以及我们在不久的将来可能会看到的情况。

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本文引用的文献

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Reconstituting organ-level lung functions on a chip.在芯片上重建器官级肺功能。
Science. 2010 Jun 25;328(5986):1662-8. doi: 10.1126/science.1188302.
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Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity.蛙皮素功能化的金纳米粒子表现出体外和体内的癌症受体特异性。
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8760-5. doi: 10.1073/pnas.1002143107. Epub 2010 Apr 21.
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Rational design of cationic lipids for siRNA delivery.阳离子脂质体的 siRNA 递呈的合理设计。
用于突变型冠状病毒感染管理的前沿高性能纳米系统:从实验室到临床。
OpenNano. 2022 Nov-Dec;8:100078. doi: 10.1016/j.onano.2022.100078. Epub 2022 Sep 10.
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Carbon nanotubes in biomedical applications: current status, promises, and challenges.生物医学应用中的碳纳米管:现状、前景与挑战。
Carbon Lett (Korean Carbon Soc). 2022;32(5):1207-1226. doi: 10.1007/s42823-022-00364-4. Epub 2022 Jul 4.
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Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications.基于蛋白质的银纳米颗粒:合成、表征、给药及纳米医学应用。
Int J Biomater. 2025 May 26;2025:5533798. doi: 10.1155/ijbm/5533798. eCollection 2025.
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Current and Near-Future Technologies to Quantify Nanoparticle Therapeutic Loading Efficiency and Surface Coating Efficiency with Targeted Moieties.用于量化纳米颗粒治疗负载效率和靶向部分表面包被效率的当前及近期技术。
Bioengineering (Basel). 2025 Mar 31;12(4):362. doi: 10.3390/bioengineering12040362.
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Polymeric and lipidic nanoparticles in transforming anti-HIV combinational therapy: can they turn the tide?聚合物和脂质纳米颗粒在抗HIV联合治疗中的转化应用:它们能否扭转局面?
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 23. doi: 10.1007/s00210-025-04169-w.
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Extensive Review of Nanomedicine Strategies Targeting the Tumor Microenvironment in PDAC.针对胰腺癌肿瘤微环境的纳米医学策略的广泛综述
Int J Nanomedicine. 2025 Mar 17;20:3379-3406. doi: 10.2147/IJN.S504503. eCollection 2025.
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Rep Pract Oncol Radiother. 2025 Feb 19;29(6):776-788. doi: 10.5603/rpor.103524. eCollection 2024.
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J Liq Biopsy. 2023 Dec 16;3:100134. doi: 10.1016/j.jlb.2023.100134. eCollection 2024 Mar.
Nat Biotechnol. 2010 Feb;28(2):172-6. doi: 10.1038/nbt.1602. Epub 2010 Jan 17.
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Cell sheet engineering: a unique nanotechnology for scaffold-free tissue reconstruction with clinical applications in regenerative medicine.细胞片层工程:一种独特的无支架组织重建纳米技术,在再生医学中有临床应用。
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