Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Cytokine. 2010 Dec;52(3):168-74. doi: 10.1016/j.cyto.2010.07.006. Epub 2010 Aug 21.
The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n=8) or trained (trained HFD, n=8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n=8) or trained (trained ER, n=8). Trained rats ran on a treadmill at 55% VO(2max) for 60 min/day, 5 days/week, for 10 weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-α levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-α and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r=0.464), TNF-α (r=0.508); and adiponectin (r=0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. The combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect.
本研究旨在探讨有氧运动训练和能量限制对肥胖大鼠肠系膜（MEAT）和腹膜后（RPAT）白色脂肪组织中脂肪因子水平的影响。雄性 Wistar 大鼠给予标准实验室饮食（对照组）或高脂肪饮食（HFD）。15 周后，HFD 大鼠随机分为以下几组：继续给予 HFD 但不运动的大鼠（ sedentary HFD 组，n=8）或运动的大鼠（ trained HFD 组，n=8）；或给予能量限制（ ER ）但不运动的大鼠（ sedentary ER 组，n=8）或运动的大鼠（ trained ER 组，n=8）。运动组大鼠在跑步机上以 55%VO(2max)运动 60 min/d，每周 5 天，共 10 周。ER 大鼠的每日热量摄入比对照组减少 20%。ER 和有氧运动训练降低了体重、MEAT 和 RPAT 的绝对重量以及脂肪量。ER 方案降低了 IL-6、IL-10 和 TNF-α 水平，但对 RPAT 中的脂联素没有影响。另一方面，ER 和有氧运动训练方案降低了 MEAT 中的 IL-6、TNF-α 和脂联素水平。MEAT 的绝对重量与 IL-6（r=0.464）、TNF-α（r=0.508）和脂联素（r=0.342）呈正相关。这些结果表明脂肪因子水平存在组织特异性的异质性反应。两种方案（有氧运动训练和能量限制）的联合并没有产生增强的效果。
