Rosa-Neto José Cesar, Silveira Loreana Sanches
Immunometabolism Research Group, Department of Systems Biology, Institute of Biomedical Sciences 1, University of São Paulo (ICB1-USP), São Paulo 05508-000, Brazil.
Laboratory of Experimental Surgery, Department of Surgery, Clinics Hospital of the Faculty of Medicine, University of São Paulo (HC-FMUSP), São Paulo 01246-903, Brazil.
Int J Mol Sci. 2020 Dec 21;21(24):9745. doi: 10.3390/ijms21249745.
Adipose tissue is considered an endocrine organ whose complex biology can be explained by the diversity of cell types that compose this tissue. The immune cells found in the stromal portion of adipose tissue play an important role on the modulation of inflammation by adipocytokines secretion. The interactions between metabolic active tissues and immune cells, called immunometabolism, is an important field for discovering new pathways and approaches to treat immunometabolic diseases, such as obesity and cancer. Moreover, physical exercise is widely known as a tool for prevention and adjuvant treatment on metabolic diseases. More specifically, aerobic exercise training is able to increase the energy expenditure, reduce the nutrition overload and modify the profile of adipocytokines and myokines with paracrine and endocrine effects. Therefore, our aim in this review was to cover the effects of aerobic exercise training on the immunometabolism of adipose tissue in obesity and cancer, focusing on the exercise-related modification on adipose tissue or immune cells isolated as well as their interaction.
脂肪组织被认为是一个内分泌器官，其复杂的生物学特性可以通过构成该组织的细胞类型的多样性来解释。在脂肪组织基质部分发现的免疫细胞通过分泌脂肪细胞因子在炎症调节中发挥重要作用。代谢活跃组织与免疫细胞之间的相互作用，即免疫代谢，是发现治疗免疫代谢疾病（如肥胖症和癌症）新途径和方法的重要领域。此外，体育锻炼作为预防和辅助治疗代谢疾病的一种手段广为人知。更具体地说，有氧运动训练能够增加能量消耗，减少营养过剩，并改变具有旁分泌和内分泌作用的脂肪细胞因子和肌动蛋白的谱。因此，我们在本综述中的目的是涵盖有氧运动训练对肥胖症和癌症中脂肪组织免疫代谢的影响，重点关注与运动相关的对分离出的脂肪组织或免疫细胞的修饰及其相互作用。
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