Intervet Schering Plough Animal Health, Department for Virological R&D, W. de Körverstraat 35, 5831 AN Boxmeer, The Netherlands.
Vaccine. 2010 Oct 8;28(43):6989-96. doi: 10.1016/j.vaccine.2010.08.043. Epub 2010 Aug 20.
Equine influenza is a contagious disease caused by equine influenza virus which belongs to the orthomyxovirus family. Outbreaks of equine influenza cause severe economic loses to the horse industry and consequently horses in competition are required to be regularly vaccinated against equine influenza. Unlike the existing inactivated vaccines, Equilis Prequenza Te is the only one able to induce protection against clinical disease and virus excretion after a primary vaccination course consisting of two vaccine applications 4-6 weeks apart until the recommended time of the third vaccination. In this paper we describe the duration of immunity profile, tested in an experimental setting according to European legislation, of this inactivated equine influenza and tetanus combination vaccine. In addition to influenza antigen, the formulation contains a second generation ISCOM (the so called ISCOMatrix) as an adjuvant. The vaccine aims at the induction of protection from the primary vaccination course until the time of annual revaccination 12 months later, against challenge with a virulent equine influenza strain. The protection against A/equine/Kentucky/95 (H3N8) at the time of annual revaccination was evidenced by a significant reduction of clinical signs of influenza, a significant reduction of virus excretion and a significant reduction of fever. The effect of the annual revaccination on the duration of immunity against influenza and tetanus was also studied by serology. For tetanus, as a consequence of the 24 months duration of immunity, an alternating annual vaccination schedule consisting of Prequenza and Prequenza Te is proposed after the first three doses of Prequenza Te.
马流感是一种由马流感病毒引起的传染病，属于正粘病毒科。马流感的爆发会给马业造成严重的经济损失，因此，参加比赛的马需要定期接种马流感疫苗。与现有的灭活疫苗不同，Equilis Prequenza Te 是唯一一种能够在两次疫苗接种（间隔 4-6 周）后诱导对临床疾病和病毒排出的保护的疫苗，直到第三次推荐接种时间。本文根据欧洲法规，在实验环境中描述了这种马流感和破伤风联合灭活疫苗的免疫持续时间。除了流感抗原外，该配方还含有第二代 ISCOM（即所谓的 ISCOMatrix）作为佐剂。该疫苗的目的是在第一次接种疫苗后的 12 个月内，即每年加强免疫时，诱导对强毒马流感株的保护。在每年加强免疫时，对 A/equine/Kentucky/95（H3N8）的保护作用通过临床流感症状的显著减轻、病毒排出的显著减少和发热的显著减少得到证明。通过血清学研究，还研究了每年加强免疫对流感和破伤风免疫持续时间的影响。由于破伤风的免疫持续时间为 24 个月，因此建议在接种 Prequenza Te 的前三剂后，采用 Prequenza 和 Prequenza Te 交替的年度免疫计划。
