Division of Endodontics, The Ohio State University, Columbus, Ohio 43210, USA.
J Endod. 2010 Sep;36(9):1459-62. doi: 10.1016/j.joen.2010.05.012.
The purpose of this prospective, randomized study was to compare the degree of pulpal anesthesia obtained in vital, asymptomatic teeth by using 1.8 mL and 3.6 mL of 2% lidocaine with 1:50,000 epinephrine compared with 1.8 mL of 2% lidocaine with 1:100,000 epinephrine for inferior alveolar nerve (IAN) block.
Thirty adult subjects randomly received IAN blocks of 1.8 mL and 3.6 mL of 2% lidocaine with 1:50,000 epinephrine and 1.8 mL of 2% lidocaine with 1:100,000 epinephrine at 3 separate appointments in a crossover design. An electric pulp tester was used to test for anesthesia in 3-minute cycles for 60 minutes of the first molars, first premolars, and lateral incisors. Anesthesia was considered successful when 2 consecutive 80 readings were obtained within 15 minutes, and the 80 reading was continuously sustained through the 60th minute.
By using 1.8 mL of 2% lidocaine with 1:50,000 epinephrine, successful pulpal anesthesia ranged from 33%-50%, and when using 3.6 mL of 2% lidocaine with 1:50,000 epinephrine, success ranged from 40%-60%. When using 1.8 mL of 2% lidocaine with 1:100,000 epinephrine, success ranged from 40%-60%, with no significant difference among the 3 anesthetic formulations.
Increasing the epinephrine concentration to 1:50,000 epinephrine or increasing the volume to 3.6 mL of 2% lidocaine with 1:50,000 epinephrine did not result in more successful pulpal anesthesia when compared with 1.8 mL of 2% lidocaine with 1:100,000 epinephrine by using the IAN block.
本前瞻性、随机研究的目的是比较在有活力、无症状的牙齿中使用 1.8 毫升和 3.6 毫升 2%利多卡因加 1:50000 肾上腺素与使用 1.8 毫升 2%利多卡因加 1:100000 肾上腺素行下牙槽神经（IAN）阻滞时所获得的牙髓麻醉程度。
30 名成年受试者以交叉设计的方式在 3 次不同的就诊中分别接受了 IAN 阻滞，注射 1.8 毫升和 3.6 毫升 2%利多卡因加 1:50000 肾上腺素以及 1.8 毫升 2%利多卡因加 1:100000 肾上腺素。在 60 分钟内每隔 3 分钟使用电牙髓测试仪测试第一磨牙、第一前磨牙和侧切牙的麻醉情况。当在 15 分钟内连续获得 2 次 80 读数且 80 读数持续维持到第 60 分钟时，即认为麻醉成功。
使用 1.8 毫升 2%利多卡因加 1:50000 肾上腺素时，牙髓麻醉成功率为 33%-50%，而使用 3.6 毫升 2%利多卡因加 1:50000 肾上腺素时，成功率为 40%-60%。使用 1.8 毫升 2%利多卡因加 1:100000 肾上腺素时，成功率为 40%-60%，3 种麻醉配方之间无显著差异。
与使用 1.8 毫升 2%利多卡因加 1:100000 肾上腺素的 IAN 阻滞相比，将肾上腺素浓度增加至 1:50000 或将体积增加至 3.6 毫升 2%利多卡因加 1:50000 肾上腺素并未导致牙髓麻醉更成功。
