Center for Biomedical Engineering and Technology, Department of Anatomy and Neurology, University of Maryland, Baltimore, Baltimore, MD, USA.
Autophagy. 2010 Oct;6(7):979-80. doi: 10.4161/auto.6.7.13118. Epub 2010 Oct 23.
Ubiquilin proteins are conserved across all eukaryotes and function in the regulation of protein degradation. We found that ubiquilin functions to regulate macroautophagy and that the protein is also a substrate of chaperone-mediated autophagy.
泛素结合蛋白在所有真核生物中都保守存在，其功能是调节蛋白质降解。我们发现泛素结合蛋白可调节巨自噬，而且该蛋白也是伴侣介导的自噬的底物。
