泛素结合酶在蛋白降解途径中的十字路口。
Ubiquilin at a crossroads in protein degradation pathways.
机构信息
Center for Biomedical Engineering and Technology, Department of Anatomy and Neurology, University of Maryland, Baltimore, Baltimore, MD, USA.
出版信息
Autophagy. 2010 Oct;6(7):979-80. doi: 10.4161/auto.6.7.13118. Epub 2010 Oct 23.
Abstract
Ubiquilin proteins are conserved across all eukaryotes and function in the regulation of protein degradation. We found that ubiquilin functions to regulate macroautophagy and that the protein is also a substrate of chaperone-mediated autophagy.
摘要
泛素结合蛋白在所有真核生物中都保守存在，其功能是调节蛋白质降解。我们发现泛素结合蛋白可调节巨自噬，而且该蛋白也是伴侣介导的自噬的底物。
相似文献
1
Ubiquilin at a crossroads in protein degradation pathways.泛素结合酶在蛋白降解途径中的十字路口。
Autophagy. 2010 Oct;6(7):979-80. doi: 10.4161/auto.6.7.13118. Epub 2010 Oct 23.
2
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.泛素在自噬中起作用，并通过伴侣介导的自噬降解。
Hum Mol Genet. 2010 Aug 15;19(16):3219-32. doi: 10.1093/hmg/ddq231. Epub 2010 Jun 7.
3
Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein.泛素蛋白 1 是淀粉样前体蛋白的分子伴侣。
J Biol Chem. 2011 Oct 14;286(41):35689-35698. doi: 10.1074/jbc.M111.243147. Epub 2011 Aug 18.
4
Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.蛋白酶体靶向因子泛素连接蛋白1对肌萎缩侧索硬化症（ALS）相关的TDP-43聚集的增强作用。
J Biol Chem. 2009 Mar 20;284(12):8083-92. doi: 10.1074/jbc.M808064200. Epub 2008 Dec 26.
5
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.泛素连接蛋白的鉴定，一种新型的早老素相互作用蛋白，可增加早老素蛋白的积累。
J Cell Biol. 2000 Nov 13;151(4):847-62. doi: 10.1083/jcb.151.4.847.
6
Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.泛素连接蛋白作为伴侣蛋白并对线粒体膜蛋白进行分类以便降解。
Mol Cell. 2016 Jul 7;63(1):21-33. doi: 10.1016/j.molcel.2016.05.020. Epub 2016 Jun 23.
7
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.泛素结合酶 4 是一种衔接蛋白，可将泛素结合酶 1 招募到自噬机器中。
EMBO Rep. 2013 Apr;14(4):373-81. doi: 10.1038/embor.2013.22. Epub 2013 Mar 5.
8
Ubiquilin-1 and protein quality control in Alzheimer disease.泛素结合酶 1 和阿尔茨海默病中的蛋白质质量控制。
Prion. 2013 Mar-Apr;7(2):164-9. doi: 10.4161/pri.23711. Epub 2013 Jan 29.
9
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.PLIC蛋白或泛素蛋白在营养饥饿期间调节自噬依赖性细胞存活。
EMBO Rep. 2009 Feb;10(2):173-9. doi: 10.1038/embor.2008.238. Epub 2009 Jan 16.
10
Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity.泛素连接蛋白过表达可减少绿色荧光蛋白-聚丙氨酸诱导的蛋白质聚集体和毒性。
Exp Cell Res. 2007 Aug 1;313(13):2810-20. doi: 10.1016/j.yexcr.2007.04.006. Epub 2007 Apr 6.
引用本文的文献
1
UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential.泛素样蛋白2在神经退行性疾病中的作用：机制洞察与新兴治疗潜力
Biochem Soc Trans. 2025 Jul 14. doi: 10.1042/BST20253053.
2
Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2.轴突导向基因调节 ALS 相关 UBQLN2 的神经毒性。
Elife. 2023 Apr 11;12:e84382. doi: 10.7554/eLife.84382.
3
Proteostasis and Ribostasis Impairment as Common Cell Death Mechanisms in Neurodegenerative Diseases.蛋白质稳态和核糖体稳态受损作为神经退行性疾病常见的细胞死亡机制
J Clin Neurol. 2023 Mar;19(2):101-114. doi: 10.3988/jcn.2022.0379.
4
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.UBQLN2 中的 ALS/FTD 突变通过在线粒体蛋白输入中丧失功能与线粒体功能障碍相关。
Hum Mol Genet. 2021 Jun 17;30(13):1230-1246. doi: 10.1093/hmg/ddab116.
5
Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins.脑表达泛素的共享和差异相分离及聚集特性。
Sci Rep. 2021 Jan 11;11(1):287. doi: 10.1038/s41598-020-78775-4.
6
The specificity of ubiquitin binding to ubiquilin-1 is regulated by sequences besides its UBA domain.泛素结合到泛素结合蛋白 1 的特异性除了受其 UBA 结构域调控外，还受其他序列调控。
Biochim Biophys Acta Gen Subj. 2019 Oct;1863(10):1568-1574. doi: 10.1016/j.bbagen.2019.06.002. Epub 2019 Jun 6.
7
The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy.泛素结合蛋白穿梭在泛素蛋白酶体系统和自噬中对泛素化蛋白的降解命运中的作用。
Cells. 2019 Jan 10;8(1):40. doi: 10.3390/cells8010040.
8
Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease.自噬-溶酶体途径与泛素-蛋白酶体系统之间的相互作用：阿尔茨海默病治疗开发的一个靶点
Front Cell Neurosci. 2018 May 9;12:126. doi: 10.3389/fncel.2018.00126. eCollection 2018.
9
Clinical significance of ubiquilin 1 in gastric cancer.泛素连接酶1在胃癌中的临床意义
Medicine (Baltimore). 2018 Jan;97(3):e9701. doi: 10.1097/MD.0000000000009701.
10
Cdc48 and ubiquilins confer selective anterograde protein sorting and entry into the multivesicular body in yeast.Cdc48 和泛素结合蛋白赋予酵母选择性的正向蛋白分拣和进入多泡体的能力。
Mol Biol Cell. 2018 Apr 15;29(8):948-963. doi: 10.1091/mbc.E17-11-0652. Epub 2018 Mar 30.
本文引用的文献
1
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.泛素在自噬中起作用，并通过伴侣介导的自噬降解。
Hum Mol Genet. 2010 Aug 15;19(16):3219-32. doi: 10.1093/hmg/ddq231. Epub 2010 Jun 7.
Zotero 插件