《捣蛋分子？肿瘤微环境中的 IL-17/Th17》
Up for Mischief? IL-17/Th17 in the tumour microenvironment.
机构信息
Centre for Cancer and Inflammation, Institute of Cancer, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
出版信息
Oncogene. 2010 Oct 21;29(42):5653-62. doi: 10.1038/onc.2010.367. Epub 2010 Aug 23.
Abstract
The role of interleukin (IL)-17 and the IL-17-producing T helper (Th)17 cells in cancer has recently become the focus of extensive investigation. An expanding body of literature implicates Th17 cells and their hallmark cytokine in both pro- and anti-tumourigenic processes. In this review we describe their biological activities and outline the reciprocal interactions between Th17 cells and other cells of the immune system. We also discuss the evidence regarding their dual role in the tumour microenvironment. An understanding of the processes that regulate the pro- or anti-tumour activities of Th17 cell and IL-17 will allow the development of more effective means for cancer immunotherapy.
摘要
白细胞介素（IL）-17 和产生白细胞介素-17 的辅助性 T 细胞（Th）17 在癌症中的作用最近成为广泛研究的焦点。越来越多的文献表明 Th17 细胞及其标志性细胞因子参与了肿瘤的发生和发展。在这篇综述中，我们描述了它们的生物学活性，并概述了 Th17 细胞与免疫系统其他细胞之间的相互作用。我们还讨论了它们在肿瘤微环境中双重作用的证据。了解调节 Th17 细胞和 IL-17 的抗肿瘤或促肿瘤活性的过程将为癌症免疫治疗的发展提供更有效的手段。
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本文引用的文献
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IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells.白细胞介素-17 通过诱导肿瘤部位的肿瘤促进微环境和髓系来源的抑制性细胞来促进肿瘤的发展。
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