Actis Paolo, Mak Andy C, Pourmand Nader
Bioanal Rev. 2010 Aug;1(2-4):177-185. doi: 10.1007/s12566-010-0013-y. Epub 2010 Jun 19.
Nanopipette technology has been proven to be a label-free biosensor capable of identifying DNA and proteins. The nanopipette can include specific recognition elements for analyte discrimination based on size, shape, and charge density. The fully electrical read-out and the ease and low-cost fabrication are unique features that give this technology an enormous potential. Unlike other biosensing platforms, nanopipettes can be precisely manipulated with submicron accuracy and used to study single cell dynamics. This review is focused on creative applications of nanopipette technology for biosensing. We highlight the potential of this technology with a particular attention to integration of this biosensor with single cell manipulation platforms.
纳米吸管技术已被证明是一种能够识别DNA和蛋白质的无标记生物传感器。纳米吸管可以包括基于大小、形状和电荷密度用于分析物鉴别的特定识别元件。全电学读出以及易于制造且成本低廉是赋予该技术巨大潜力的独特特性。与其他生物传感平台不同，纳米吸管可以以亚微米精度进行精确操控，并用于研究单细胞动态。本综述聚焦于纳米吸管技术在生物传感方面的创新性应用。我们强调这项技术的潜力，尤其关注这种生物传感器与单细胞操控平台的整合。
