Vieira P M, Santos S C, Chen-Chen L
Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Braz J Biol. 2010 Aug;70(3):601-6. doi: 10.1590/s1519-69842010000300017.
Solanum paniculatum L. is a plant species widespread throughout tropical America, especially in the Brazilian Savanna region. It is used in Brazil for culinary purposes and in folk medicine to treat liver and gastric dysfunctions, as well as hangovers. Because of the wide use of this plant as a therapeutic resource and food, the present study aimed at evaluating the mutagenic and cytotoxic effects of S. paniculatum ethanolic leaf and fruit extracts using the mouse bone marrow micronucleus test. Our results indicate that neither S. paniculatum ethanolic leaf extract nor its ethanolic fruit extract exhibited mutagenic effect in mice bone marrow; however, at higher doses, both extracts presented cytotoxic activity.
刺天茄是一种广泛分布于热带美洲的植物物种，特别是在巴西热带稀树草原地区。在巴西，它被用于烹饪，在民间医学中用于治疗肝脏和胃部功能障碍以及宿醉。由于这种植物作为治疗资源和食物的广泛使用，本研究旨在使用小鼠骨髓微核试验评估刺天茄乙醇叶和果实提取物的诱变和细胞毒性作用。我们的结果表明，刺天茄乙醇叶提取物及其乙醇果实提取物在小鼠骨髓中均未表现出诱变作用；然而，在较高剂量下，两种提取物均呈现出细胞毒性活性。
