Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, Kerala, India.
J Ethnopharmacol. 2010 Nov 11;132(2):456-60. doi: 10.1016/j.jep.2010.08.038. Epub 2010 Aug 21.
Drynaria quercifolia (L.) J. Smith (Polypodiaceae), has been widely used by ethnic groups of India to treat inflammation, rheumatism, headache, bone fracture, jaundice, etc.
To evaluate the anti-inflammatory and analgesic properties of the ethanolic extract of rhizome of Drynaria quercifolia (DQ) and its phytochemical profile.
DQ was used to evaluate the anti-inflammatory and analgesic effects using carrageenan-induced paw oedema/cotton pellet-induced granuloma in Wistar rats and acetic acid-induced writhing/formalin-induced paw licking test in Swiss albino mice respectively.
Oral administration of DQ produced significant inhibition of carrageenan-induced paw oedema and granuloma formation in rats, almost comparable to that caused by indomethacin. DQ significantly attenuated acute and delayed phases of formalin-induced pain and acetic acid-induced writhing episodes in mice. The analgesia was comparable to that produced by sodium salicylate and aspirin respectively. Phytochemical analysis gave positive tests for catechin, coumarins, flavonoids, phenolics, saponin, steroids, tannins, and triterpenes. The total phenolics in DQ was 244 mg/g and naringin content was 0.048%.
The results suggest the presence of potent anti-inflammatory and analgesic principles in DQ that justifies its use for alleviating painful inflammatory conditions.
槲蕨（Polypodiaceae）已被印度各民族广泛用于治疗炎症、风湿病、头痛、骨折、黄疸等。
评估槲蕨根茎的乙醇提取物的抗炎和镇痛特性及其植物化学特征。
使用角叉菜胶诱导的足肿胀/棉粒诱导的肉芽肿来评估 DQ 的抗炎和镇痛作用，以及在瑞士白化小鼠中用醋酸诱导的扭体/福尔马林诱导的舔足试验。
DQ 的口服给药对大鼠角叉菜胶诱导的足肿胀和肉芽肿形成具有显著的抑制作用，几乎可与吲哚美辛相当。DQ 显著减轻了福尔马林诱导的疼痛的急性和延迟相以及醋酸诱导的扭体发作。镇痛作用可与水杨酸钠和阿司匹林相当。植物化学分析对儿茶素、香豆素、类黄酮、酚类、皂苷、类固醇、单宁和三萜类化合物呈阳性反应。DQ 中的总酚含量为 244mg/g，柚皮苷含量为 0.048%。
结果表明 DQ 中存在有效的抗炎和镇痛成分，这证明了其用于缓解疼痛炎症的合理性。
