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[水溶性α-生育酚在与氧气接触时对人红细胞膜的影响]

[The effect of alpha-tocopherol in water-soluble form on human erythrocyte membranes while in contact with oxygen].

作者信息

Verbolovich V P, Podgornyĭ Iu K, Podgornaia L M, Evstigneeva R P, Alekseev S M, Zakharova E I

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1990(11):35-42.

PMID:2073531
Abstract

The effect of water soluble tocopherol forms (dipotassium salt d,l-alpha-tocopheryl-phosphate) on lipid peroxidation induced by oxygen in membranes of human erythrocytes has been studied. An erythrocyte was considered as a structure reflecting the state of plasmatic membranes of organs and tissues. It has been established that this substance doses optimum for membrane protection against lipid peroxidation are not in excess of 1.5-5.0 mg per 1 kg of human body mass; the dose by an order higher may exert a toxic effect.

摘要

研究了水溶性生育酚形式(二钾盐d,l-α-生育酚磷酸酯)对人红细胞膜中由氧诱导的脂质过氧化的影响。红细胞被视为反映器官和组织质膜状态的结构。已确定该物质对膜保护免受脂质过氧化的最佳剂量不超过每1千克人体质量1.5 - 5.0毫克;高出一个数量级的剂量可能会产生毒性作用。

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