Institute of Statistics, Academia Sinica, Taipei, Taiwan, ROC.
Mol Biotechnol. 2011 Jan;47(1):70-82. doi: 10.1007/s12033-010-9325-y.
Metabolic reactions and gene regulation are two primary processes of cells. In response to environmental changes cells often adjust the regulatory programs and shift the metabolic states. An integrative investigation and modeling of these two processes would improve our understanding about the cellular systems and may generate substantial impacts in medicine, agriculture, environmental protection, and energy production. We review the studies of the various aspects of the crosstalk between metabolic reactions and gene regulation, including models, empirical evidence, and available databases.
代谢反应和基因调控是细胞的两个主要过程。细胞通常会调整调控程序并改变代谢状态，以应对环境变化。对这两个过程进行综合研究和建模将提高我们对细胞系统的理解，并可能在医学、农业、环境保护和能源生产等领域产生重大影响。我们综述了代谢反应和基因调控之间相互作用的各个方面的研究，包括模型、经验证据和现有数据库。
