Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK.
Mov Disord. 2010 Oct 15;25(13):2249-52. doi: 10.1002/mds.23250.
Myoclonus dystonia and idiopathic dystonia are associated with a greater frequency of obsessive compulsive disorder (OCD) and major depression. We investigated the frequency of OCD in 39 patients with primary focal hand dystonia (FHD) using a semistructured interview. OCD and subsyndromal OCD was diagnosed in 5 of 39 (12.82%) patients with FHD, whereas OCD occurs in 2.3% of the general population. Recurrent depression occurred in (7 of 39) 17.95% of patients with FHD along with a family history of depression in (16 of 39) 41.02%. Overlapping mechanisms manifesting as FHD may also predispose to OC symptoms and likely implicates a common striatal dysfunction.
肌阵挛性肌张力障碍和特发性肌张力障碍与强迫症（OCD）和重度抑郁症的发病率更高相关。我们使用半结构化访谈调查了 39 名原发性局灶性手部肌张力障碍（FHD）患者中 OCD 的发病率。5 例（12.82%）FHD 患者诊断为 OCD 和亚临床 OCD，而 OCD 在普通人群中的发病率为 2.3%。复发性抑郁在 39 例患者中的 7 例（17.95%）中出现，FHD 患者的家族史中有抑郁在 16 例（41.02%）中出现。表现为 FHD 的重叠机制也可能导致 OC 症状，并可能暗示纹状体功能障碍的常见原因。
