Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania 19140, USA.
Adv Exp Med Biol. 2010;678:133-7. doi: 10.1007/978-1-4419-6306-2_17.
This chapter describes quantitative methodology that is directed toward assessing interactions between a combination of agonist drugs that individually produce overtly similar effects. Drugs administered in combination may show exaggerated, reduced or predictable effects that are dependent on the specific drug pair and the doses of t h e constituents. The basisfor quantitating these unusual interactions is the concept of dose equivalence which, in turn, is determined from the individual drug dose-effect relations. A common analytical procedure that follows from dose equivalence uses a graph termed an isobologram. We present here an overview of the isobologram, its use and certain related methods that apply to classifying various drug interactions.
本章描述了一种定量方法，旨在评估单独产生明显相似作用的一组激动剂药物之间的相互作用。联合用药可能会产生夸大、减少或可预测的效果，这些效果取决于特定的药物对和成分的剂量。定量这些不寻常相互作用的基础是剂量等效性的概念，而剂量等效性又是由个体药物剂量-效应关系决定的。从剂量等效性得出的一种常见分析程序是使用一种称为等效应线的图。我们在这里概述了等效应线及其用途，以及适用于分类各种药物相互作用的某些相关方法。
