Elamin A, Tuvemo T
Department of Paediatrics & Child Health, Faculty of Medicine, University of Khartoum, Sudan.
Diabetes Res Clin Pract. 1990 Nov-Dec;10(3):203-9. doi: 10.1016/0168-8227(90)90062-x.
There is accumulating evidence that the changes which occur in the metabolism of some micronutrients in diabetes mellitus might have a specific role in the pathogenesis and complications of this disease. Magnesium deficiency is the most evident disturbance of metal metabolism in insulin-dependent diabetes mellitus. Hypomagnesemia has been linked both to the acute metabolic and late chronic complication of diabetes. Of particular concern, is the association between hypomagnesemia and ischemic heart disease and severe retinopathy in humans with diabetes mellitus. Appropriate magnesium supplementation might prove beneficial in normalizing the low plasma and tissue magnesium levels and prevent or retard the development of vascular complications in diabetic patients. However, well designed and documented experiments need to be performed before the rationales for such therapy are well established.
越来越多的证据表明，糖尿病患者某些微量营养素代谢发生的变化可能在该疾病的发病机制和并发症中起特定作用。镁缺乏是胰岛素依赖型糖尿病中最明显的金属代谢紊乱。低镁血症与糖尿病的急性代谢和晚期慢性并发症均有关联。特别值得关注的是，糖尿病患者中低镁血症与缺血性心脏病和严重视网膜病变之间的关联。适当补充镁可能有助于使低血浆和组织镁水平恢复正常，并预防或延缓糖尿病患者血管并发症的发展。然而，在充分确立这种治疗的理论依据之前，需要进行精心设计和记录的实验。
