Sharma Aradhana, Dabla Surekha, Agrawal R P, Barjatya H, Kochar D K, Kothari R P
Department of Medicine, SP Medical College, Bikaner 334003.
J Indian Med Assoc. 2007 Jan;105(1):16, 18, 20.
The aim of this study was to evaluate relationship between serum magnesium and course of diabetes mellitus and also to find out, if there is any relation between serum magnesium and various complications of diabetes mellitus. A cross-sectional study was conducted to examine the relationship between serum magnesium in 50 type 1 and type 2 diabetic patients with or without complications and 40 normal healthy persons. Serum magneisum estimation was done using calmagite dye method using autoanalyser (Beckman DU clin systems). Serum magnesium levels in diabetic population was significantly low (1.93 +/- 0.282 meq/l) in comparison to control (2.25 +/- 0.429 meq/l). It was statistically significant (+3.84; p < 0.005). Serum magnesium was significantly low in diabetes with complication than without complications (p < 0.001). Duration of diabetes and serum magnesium were inversely related. Poor glycaemic control was associated with hypomagnesaemia (-2.623; p < 0.05). There was strong association between hypomagnesaemia and retinopathy (1.76 +/- 0.26), obesity (1.878 +/- 0.326) and hypertension (1.75 +/- 0.071) and it was statistically significantly (p < 0.005, 0.042, 0.000 respectively). Hence it is concluded that the change in serum magnesium level may have a bearing on the complication and morbidity in patients of diabetes mellitus.
本研究的目的是评估血清镁与糖尿病病程之间的关系，并找出血清镁与糖尿病各种并发症之间是否存在关联。开展了一项横断面研究，以检查50例有或无并发症的1型和2型糖尿病患者以及40例正常健康人的血清镁之间的关系。使用自动分析仪（贝克曼DU临床系统）采用钙镁试剂染料法进行血清镁测定。与对照组（2.25±0.429毫当量/升）相比，糖尿病患者群体的血清镁水平显著降低（1.93±0.282毫当量/升）。具有统计学意义（+3.84；p<0.005）。有并发症的糖尿病患者血清镁水平显著低于无并发症者（p<0.001）。糖尿病病程与血清镁呈负相关。血糖控制不佳与低镁血症相关（-2.623；p<0.05）。低镁血症与视网膜病变（1.76±0.26）、肥胖（1.878±0.326）和高血压（1.75±0.071）之间存在强关联，且具有统计学意义（分别为p<0.005、0.042、0.000）。因此得出结论，血清镁水平的变化可能与糖尿病患者的并发症和发病率有关。
