Baggott Christina, Dodd Marylin, Kennedy Christine, Marina Neyssa, Matthay Katherine K, Cooper Bruce A, Miaskowski Christine
University of California San Francisco, San Francisco, CA 94143, USA.
J Pediatr Oncol Nurs. 2010 Nov-Dec;27(6):307-15. doi: 10.1177/1043454210377619. Epub 2010 Aug 25.
The purposes of this study in children who underwent a cycle of myelosuppressive chemotherapy were to describe changes in symptom occurrence and severity during the chemotherapy cycle. Patients (N = 66) 10 to 18 years of age completed the Memorial Symptom Assessment Scale for 10- to 18-year-olds (MSAS 10-18) at the start of a chemotherapy cycle (T1) and weekly for the next 2 weeks (T2 and T3). More than 30% of children reported 10 or more symptoms at all 3 time points. Symptom occurrence trajectories were tested with multilevel logistic regression. In all, 6 symptoms (ie, fatigue, sadness, irritability, worrying, weight loss, sweating) showed a decreasing linear trend. Significant quadratic patterns of change were found for feeling drowsy, nausea, and vomiting. Changes in symptom severity over time were evaluated with multilevel negative binomial regression. No significant differences over time were found in any of the symptom severity scores on the MSAS. Children experienced a high number of symptoms at the initiation of a chemotherapy cycle that persisted over the subsequent 2 weeks.
本研究针对接受了一个周期骨髓抑制性化疗的儿童，目的是描述化疗周期中症状出现情况及严重程度的变化。10至18岁的患者（N = 66）在化疗周期开始时（T1）完成了针对10至18岁儿童的纪念症状评估量表（MSAS 10 - 18），并在接下来的2周内每周完成一次（T2和T3）。超过30%的儿童在所有3个时间点报告了10种或更多症状。症状出现轨迹通过多水平逻辑回归进行检验。总体而言，6种症状（即疲劳、悲伤、易怒、担忧、体重减轻、出汗）呈现出下降的线性趋势。发现嗜睡、恶心和呕吐存在显著的二次变化模式。通过多水平负二项回归评估症状严重程度随时间的变化。在MSAS上，任何症状严重程度得分随时间均未发现显著差异。儿童在化疗周期开始时出现大量症状，这些症状在随后的2周内持续存在。
