Teoh Deanna, Freedman Ralph, Soliman Pamela T
Department of Gynecologic Oncology, Duke University, Durham, N.C., USA.
Case Rep Oncol. 2010 Jan 13;3(1):14-18. doi: 10.1159/000274590.
A 30-year-old woman was diagnosed with a stage IA granulosa cell tumor (GCT) of the ovary in 1979. Following removal of the adnexal mass and complete surgical staging, she remained disease-free for 12 years. In 1991 she underwent a resection of a retroperitoneal mass, confirmed to be a recurrent GCT. Despite adjuvant radiation treatment at the time of recurrence, the patient presented five years later with abdominal pain, and was found to have a second recurrence. Over the next 10 years the patient had multiple recurrences and progressive disease despite surgical resection, cytotoxic, hormonal and targeted chemotherapy treatments. In conclusion, there is no standard management for recurrent GCT of the ovary. We review this patient's treatment in the context of the current literature.
一名30岁女性于1979年被诊断为卵巢IA期颗粒细胞瘤（GCT）。在切除附件肿块并完成全面手术分期后，她无病生存了12年。1991年，她接受了腹膜后肿块切除术，证实为复发性GCT。尽管复发时进行了辅助放疗，但患者5年后出现腹痛，被发现有第二次复发。在接下来的10年里，尽管进行了手术切除、细胞毒性、激素和靶向化疗治疗，患者仍多次复发且病情进展。总之，卵巢复发性GCT尚无标准的治疗方法。我们结合当前文献对该患者的治疗进行了回顾。
