Bosello O, Zamboni M, Armellini F, Zocca I, Bergamo Andreis I A, Smacchia C, Milani M P, Cominacini L
Istituto di Clinica Medica, Università di Verona, Italia.
Ann Nutr Metab. 1990;34(6):359-65. doi: 10.1159/000177610.
Using computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose and insulin levels, oral glucose tolerance test, basal pancreatic insulin secretion estimated by fasting C peptide (Cp), and fasting insulin hepatic clearance calculated by Cp/insulin molar ratio. After VLCD the body weight and body mass index significantly declined (p less than 0.01); whereas abdominal adipose tissue and visceral abdominal tissue (VAT) significantly decreased (p less than 0.01), modifications of subcutaneous abdominal tissue (SAT) were not significant. Fasting insulin levels and plasma glucose response to oral glucose load significantly decreased (p less than 0.05). Insulin response remained unchanged. Cp immunoreactive insulin (IRI) significantly increased (p less than 0.01). A significant positive correlation was found between delta VAT and delta Cp/IRI before and after VLCD (p less than 0.01). Our data seem to suggest that the weight loss induced by VLCD fundamentally involves a decrease in VAT. The reduction in visceral fat could be associated with an increase in hepatic insulin clearance.
我们对19名肥胖女性受试者进行了计算机断层扫描，测定了她们在极低热量饮食（VLCD）2周前后的腹部脂肪组织，包括皮下脂肪组织和内脏脂肪组织。在VLCD 15 - 20天后，还测定了以下参数：血糖和胰岛素水平、口服葡萄糖耐量试验、通过空腹C肽（Cp）估算的基础胰腺胰岛素分泌，以及通过Cp/胰岛素摩尔比计算的空腹胰岛素肝脏清除率。VLCD后，体重和体重指数显著下降（p < 0.01）；而腹部脂肪组织和内脏腹部组织（VAT）显著减少（p < 0.01），腹部皮下组织（SAT）的变化不显著。空腹胰岛素水平和口服葡萄糖负荷后的血浆葡萄糖反应显著降低（p < 0.05）。胰岛素反应保持不变。Cp免疫反应性胰岛素（IRI）显著增加（p < 0.01）。在VLCD前后，VAT的变化量与Cp/IRI的变化量之间发现显著正相关（p < 0.01）。我们的数据似乎表明，VLCD引起的体重减轻主要涉及VAT的减少。内脏脂肪的减少可能与肝脏胰岛素清除率的增加有关。
