Harjacek M, Batinić D, Sarnavka V, Uzarević B, Mardesić D, Marusić M
Department of Paediatrics, University Hospital Rebro, Croatia, Yugoslavia.
Eur J Pediatr. 1990 Nov;150(1):40-2. doi: 10.1007/BF01959478.
A thorough analysis of the immunological status was conducted in a 15-month-old child with progeria (Hutchinson-Gilford syndrome). Total leukocyte and neutrophil counts were slightly increased, and monocytes were decreased. Percentage and numbers of CD4+ cells in the blood were mildly decreased as well as the CD4/CD8 cell ratio. CD20 (B-cell marker) bearing cells and cells bearing Ia-antigens were increased, as well as CD16 and CD56 marker-bearing cells (natural-killer cells, NK). Lymphocyte proliferation upon stimulation with phytohaemagglutinin and purified protein derivative were decreased, and with pokeweed mitogen increased. NK cell activity appeared increased, particularly at lower effector: target cell ratios.
对一名患有早老症（哈钦森-吉尔福德综合征）的15个月大儿童进行了全面的免疫状态分析。白细胞和中性粒细胞总数略有增加，单核细胞减少。血液中CD4+细胞的百分比和数量以及CD4/CD8细胞比值均轻度降低。携带CD20（B细胞标志物）的细胞和携带Ia抗原的细胞增加，以及携带CD16和CD56标志物的细胞（自然杀伤细胞，NK）增加。用植物血凝素和纯化蛋白衍生物刺激后淋巴细胞增殖减少，用商陆有丝分裂原刺激后淋巴细胞增殖增加。NK细胞活性似乎增加，尤其是在较低的效应细胞：靶细胞比值时。
