Gupta S
Gerontology. 1981;27(4):181-6. doi: 10.1159/000212471.
Peripheral blood from 4 patients with progeria and their family members and 2 patients with Werner's syndrome were analyzed for the proportion of total T cells and T cells with receptors for IgM (Tmu) or IgG (Tgamma). In 3 patients proportions of Tmu cells were within the range for age- and sex-matched controls. 1 patient had significantly lower proportions of Tmu cells when compared to age- and sex-matched controls. The proportions of Tgamma cells were increased in 2 and were within the range for normal controls in the remaining 2 patients. When data were analyzed with regard to Tmu/Tgamma ratios, 3 of 4 patients exhibited ratios lower than the lowest limit observed in age- and sex-matched controls. Surprisingly, family members in all four families exhibited patterns of Tmu and Tgamma cells similar to that seen in the patient. Both patients with Werner's syndrome had proportions of Tgamma cells, resulting in low Tmu/Tgamma ratios.
对4名早衰症患者及其家庭成员以及2名沃纳综合征患者的外周血进行分析，以检测总T细胞以及带有IgM受体的T细胞（Tmu）或IgG受体的T细胞（Tgamma）的比例。3名患者的Tmu细胞比例在年龄和性别匹配的对照组范围内。与年龄和性别匹配的对照组相比，1名患者的Tmu细胞比例显著降低。2名患者的Tgamma细胞比例升高，其余2名患者的Tgamma细胞比例在正常对照组范围内。当分析Tmu/Tgamma比值的数据时，4名患者中有3名的比值低于年龄和性别匹配的对照组中观察到的最低限度。令人惊讶的是，所有四个家庭的家庭成员的Tmu和Tgamma细胞模式与患者相似。两名沃纳综合征患者的Tgamma细胞比例导致Tmu/Tgamma比值较低。
