Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, USA.
Org Lett. 2010 Oct 1;12(19):4224-7. doi: 10.1021/ol101523z.
A total synthesis of rhazinilam based on a transannular cyclization strategy is described. Using a Heck reaction, the axial chirality of a halogenated 13-membered lactam can be exploited to create the quaternary chiral stereogenic center in the target molecule with high enantiospecificity.
基于环加成策略的雷沙吉兰全合成描述。利用 Heck 反应,可以利用卤代 13 元内酰胺的轴向手性来在目标分子中高对映选择性地构建季碳手性中心。