Abu-Darwish Mohammad S, Efferth Thomas
Department of Basic and Applied Sciences, Shoubak University College, Al-Balqa' Applied University, Al-Salt, Jordan.
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
Front Pharmacol. 2018 Jan 31;9:56. doi: 10.3389/fphar.2018.00056. eCollection 2018.
Cancer is one of the major problems affecting public health worldwide. As other cultures, the populations of the Near East rely on medicinal herbs and their preparations to fight cancer. We compiled data derived from historical ethnopharmacological information as well as and results and clinical findings extracted from different literature databases including (PubMed, Scopus, Web of Science, and Google Scholar) during the past two decades. In this survey, we analyzed the huge amount of data available on anticancer ethnopharmacological sources used in the Near East. Medicinal herbs are the most dominant ethnopharmacological formula used among cancer's patients in the Near East. The data obtained highlight for the first time the most commonly used medicinal plants in the Near East area for cancer treatment illustrating their importance as natural anticancer agents. The literature survey reveals that various species, various species, , , , , various species, , and others belong to the most frequently used plants among cancer patients in the Near East countries. Molecular modes of action that have been investigated for plant extracts and isolated compounds from Near East include cell cycle arrest and apoptosis induction with participation of major player in these processes such as p53 and p21, Bcl-2, Bax, cytochrome release, poly (ADP-ribose) polymerase cleavage, activation of caspases, etc. The ethnopharmacology of the Near East was influenced by Arabic and Islamic medicine and might be promising for developing new natural and safe anticancer agents. Further research is required to elucidate their cellular and molecular mechanisms and to estimate their clinical activity.
癌症是影响全球公众健康的主要问题之一。与其他文化一样，近东地区的人们依靠草药及其制剂来对抗癌症。我们收集了来自历史民族药理学信息的数据，以及过去二十年间从不同文献数据库（包括PubMed、Scopus、Web of Science和谷歌学术）中提取的结果和临床发现。在这项调查中，我们分析了近东地区用于抗癌的民族药理学来源的大量数据。草药是近东地区癌症患者中最主要使用的民族药理学配方。所获得的数据首次突出了近东地区用于癌症治疗的最常用药用植物，说明了它们作为天然抗癌剂的重要性。文献调查显示，各种[此处原文缺失植物种类具体信息]物种、各种[此处原文缺失植物种类具体信息]物种、[此处原文缺失植物种类具体信息]、[此处原文缺失植物种类具体信息]、[此处原文缺失植物种类具体信息]、各种[此处原文缺失植物种类具体信息]物种、[此处原文缺失植物种类具体信息]以及其他植物属于近东国家癌症患者中最常使用的植物。对来自近东地区的植物提取物和分离化合物所研究的分子作用模式包括细胞周期阻滞和凋亡诱导，这些过程中主要参与者如p53、p21、Bcl - 2、Bax、细胞色素[此处原文缺失具体名称]释放、聚（ADP - 核糖）聚合酶裂解、半胱天冬酶激活等参与其中。近东地区的民族药理学受到阿拉伯和伊斯兰医学的影响，可能在开发新的天然和安全抗癌剂方面具有前景。需要进一步研究以阐明其细胞和分子机制并评估其临床活性。
