Memory Center, CHU - University of Nice Sophia Antipolis, Hôpital de Cimiez, 4 av Victoria, 06000 Nice, France.
Alzheimers Res Ther. 2010 Aug 26;2(4):24. doi: 10.1186/alzrt48.
The present review of Alzheimer's disease (AD) rating scales aims to outline the need for a new rating scale to be used in routine clinical practice for long-term medical care of AD patients. An ideal scale would be: 1) practical, easy and quick to administer for an experienced clinician; 2) validated for AD; 3) multi-domain: covering the AD-relevant areas of cognition, activities of daily living, behavior, communication/social interaction, and quality of life; 4) applicable to all AD severity stages; 5) able to monitor disease progression; and 6) sensitive to measure therapy effects.
The National Library of Medicines' MEDLINE database was searched for the years 1981 to September 2008, using a set of keywords aiming to select instruments which cover at least some of the requirements for an ideal practical AD scale for therapy evaluation. Measures for AD staging and screening tests were not considered for review.
Of 1,902 articles resulting from the literature search, 68 relevant AD scales were identified. Most of them were scales that predominantly measure the severity of major dysfunctions in particular AD domains. Only five scales met some of the requirements for a practical multi-domain AD scale, but did not possess all required characteristics.
Despite the multitude of AD scales for various purposes, there remains a need for a new multi-domain and easy to administer AD scale for assessment of disease progression and response to therapy in daily medical practice.
本综述旨在概述用于阿尔茨海默病（AD）常规临床实践长期医疗的新评级量表的需求。一个理想的量表将是：1）对于有经验的临床医生来说，实用、易于操作且快速；2）经 AD 验证；3）多领域：涵盖与 AD 相关的认知、日常生活活动、行为、沟通/社会互动和生活质量领域；4）适用于所有 AD 严重程度阶段；5）能够监测疾病进展；6）能够灵敏地衡量治疗效果。
通过一组旨在选择至少涵盖理想实用 AD 量表用于治疗评估的部分要求的关键词，在 1981 年至 2008 年 9 月期间，对美国国立医学图书馆的 MEDLINE 数据库进行了搜索。未考虑 AD 分期和筛选测试的措施。
从文献检索中得到 1902 篇文章，确定了 68 种相关的 AD 量表。其中大多数是主要测量特定 AD 领域中主要功能障碍严重程度的量表。只有 5 种量表符合实用多领域 AD 量表的一些要求，但不具备所有必需的特征。
尽管有许多用于各种目的的 AD 量表，但仍需要一种新的多领域且易于管理的 AD 量表，用于评估疾病进展和日常医疗实践中的治疗反应。
