Connor Donald J, Sabbagh Marwan N, Cummings Jeffery L
Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ, USA.
Alzheimers Dement. 2008 Nov;4(6):390-4. doi: 10.1016/j.jalz.2008.09.002.
The Neuropsychiatric Inventory (NPI) is commonly used in dementia trials to quantify and qualitate changes in psychiatric symptoms.
A questionnaire was administered to clinical trial raters to assess whether they were being trained to administer and score the NPI differently between clinical trial protocols.
Responses to the survey indicated that there are differences between clinical trials protocols in how the instrument is administered and scored.
Clarification of administration and scoring rules are provided, including the behavioral sampling period, whether premorbid characteristics are considered, and what behaviors are considered in rating frequency, severity, and caregiver distress.
神经精神科问卷（NPI）常用于痴呆症试验，以量化和定性精神症状的变化。
向临床试验评分者发放一份问卷，以评估他们是否接受培训，从而在不同的临床试验方案中对NPI进行不同的管理和评分。
调查回复表明，不同临床试验方案在该工具的管理和评分方式上存在差异。
提供了管理和评分规则的说明，包括行为抽样期、是否考虑病前特征，以及在评定频率、严重程度和照料者痛苦时考虑哪些行为。
