Montefiore Medical Center, Bronx NY, USA.
AIDS Res Ther. 2010 Aug 26;7:34. doi: 10.1186/1742-6405-7-34.
Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women.
Cross-sectional study of 824 (218 HIV-negative, 606 HIV+) Rwandan women. Body composition by body impedance analysis, CD4 count, and fasting serum total cholesterol (total-C), triglycerides (TG) and high-density lipoprotein (HDL) levels were measured. Low-density lipoprotein (LDL) was calculated from Friedewald equation if TG < 400 and measured directly if TG ≥ 400 mg/dl.
BMI was similar in HIV+ and -negative women, < 1% were diabetic, and HIV+ women were younger. In multivariate models LDL was not associated with HIV-serostatus. HDL was lower in HIV+ women (44 vs. 54 mg/dL, p < 0.0001) with no significant difference by CD4 count (p = 0.13). HIV serostatus (p = 0.005) and among HIV+ women lower CD4 count (p = 0.04) were associated with higher TG. BMI was independently associated with higher LDL (p = 0.01), and higher total body fat was strongly associated with higher total-C and LDL. Framingham risk scores were < 2% in both groups.
In this cohort of non-obese African women HDL and TG, but not LDL, were adversely associated with HIV infection. As HDL is a strong predictor of cardiovascular (CV) events in women, this HIV-associated difference may confer increased risk for CV disease in HIV-infected women.
HIV 感染的非洲女性的脂蛋白谱尚未得到很好的描述。我们评估了脂蛋白水平与心血管风险与卢旺达女性的 HIV 感染和 CD4 计数的关联。
对 824 名（218 名 HIV 阴性，606 名 HIV 阳性）卢旺达女性进行横断面研究。通过身体阻抗分析测量身体成分、CD4 计数以及空腹血清总胆固醇（总胆固醇）、甘油三酯（TG）和高密度脂蛋白（HDL）水平。如果 TG < 400，则用 Friedewald 方程计算 LDL，如果 TG ≥ 400mg/dl，则直接测量 LDL。
HIV 阳性和阴性女性的 BMI 相似，<1%为糖尿病，HIV 阳性女性更年轻。在多变量模型中，LDL 与 HIV 血清状态无关。HDL 在 HIV 阳性女性中较低（44 与 54mg/dL，p < 0.0001），但与 CD4 计数无显着差异（p = 0.13）。HIV 血清状态（p = 0.005）和 HIV 阳性女性中较低的 CD4 计数（p = 0.04）与较高的 TG 相关。BMI 与 LDL 升高独立相关（p = 0.01），而总身体脂肪与总胆固醇和 LDL 升高密切相关。两组Framingham 风险评分均<2%。
在这个非肥胖的非洲女性队列中，HDL 和 TG，但不是 LDL，与 HIV 感染呈负相关。由于 HDL 是女性心血管（CV）事件的强烈预测因子，因此 HIV 相关差异可能会使 HIV 感染女性的 CV 疾病风险增加。
