St Vincent's Institute, 9 Princes St, Fitzroy, Victoria 3065, Australia.
BMB Rep. 2010 Aug;43(8):513-23. doi: 10.5483/bmbrep.2010.43.8.513.
Cytokines that bind to and signal through the gp130 co-receptor subunit include interleukin (IL)-6, IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), and ciliary neutrophic factor (CNTF). Apart from contributing to inflammation, gp130 signalling cytokines also function in the maintenance of bone homeostasis. Expression of each of these cytokines and their ligand-specific receptors is observed in bone and joint cells, and bone-active hormones and inflammatory cytokines regulate their expression. gp130 signalling cytokines have been shown to regulate the differentiation and activity of osteoblasts, osteoclasts and chondrocytes. Furthermore, cytokine and receptor specific gene-knockout mouse models have identified distinct roles for each of these cytokines in regulating bone resorption, bone formation and bone growth. This review will discuss the current models of paracrine and endocrine actions of gp130-signalling cytokines in bone remodelling and growth, as well as their impact in pathologic bone remodelling evident in periodontal disease, rheumatoid arthritis, spondylarthropathies and osteoarthritis.
与 gp130 共受体亚基结合并发出信号的细胞因子包括白细胞介素 (IL)-6、IL-11、肿瘤坏死因子 M (OSM)、白血病抑制因子 (LIF)、心脏营养素-1 (CT-1) 和睫状神经营养因子 (CNTF)。除了参与炎症外，gp130 信号细胞因子在维持骨稳态中也具有功能。这些细胞因子及其配体特异性受体的表达在骨骼和关节细胞中观察到，骨活性激素和炎症细胞因子调节其表达。gp130 信号细胞因子已被证明可调节成骨细胞、破骨细胞和软骨细胞的分化和活性。此外，细胞因子和受体特异性基因敲除小鼠模型已确定这些细胞因子中的每一种在调节骨吸收、骨形成和骨生长中的独特作用。本综述将讨论 gp130 信号细胞因子在骨重塑和生长中的旁分泌和内分泌作用的现有模型，以及它们在牙周病、类风湿关节炎、脊柱关节病和骨关节炎中明显的病理性骨重塑中的影响。
