Wild J M, Betts T A, Shaw D E
Department of Vision Sciences, Aston University, Birmingham, UK.
Jpn J Ophthalmol. 1990;34(3):291-7.
The influence of a socially acceptable dose of alcohol (mean blood alcohol level approximately 90 minutes after ingestion 69.5 mg%; SE 6.20 mg%) on the central visual field as determined by automated static perimetry was investigated in 17 female subjects (17 eyes) trained in automated perimetry (mean age 22.5 years, SE 1.29 years). Central visual field examination was undertaken on the right eye with program 30-2 (stimulus size III) of the Humphrey Field Analyser 630, using a simple cross-over placebo design. Alcohol produced a small (1.0 dB) but statistically significant decrease in the mean deviation (P = 0.002) and small increases (0.6 dB) in the pattern and corrected pattern standard deviations (P = 0.003 and P = 0.046, respectively). The number of stimulus presentations increased by 6% (P = 0.006) and the number of false-negative responses also increased (P = 0.019), indicating impaired patient response. Attenuation of sensitivity as a result of alcohol increased with the increase in eccentricity (P = 0.046) independently of the meridian (P = 0.068) from a mean of 0.8 dB at 3 degrees eccentricity to 1.84 dB at 27 degrees.
在17名接受过自动视野计训练的女性受试者（17只眼）中（平均年龄22.5岁，标准误1.29岁），研究了社会可接受剂量的酒精（摄入后约90分钟时平均血液酒精水平为69.5mg%；标准误6.20mg%）对通过自动静态视野计测定的中心视野的影响。使用简单的交叉安慰剂设计，采用Humphrey视野分析仪630的程序30 - 2（刺激大小III）对右眼进行中心视野检查。酒精使平均偏差出现了微小（1.0dB）但具有统计学意义的降低（P = 0.002），并且使模式标准差和校正模式标准差出现了微小增加（分别为0.6dB）（P分别为0.003和0.046）。刺激呈现次数增加了6%（P = 0.006），假阴性反应次数也增加了（P = 0.019），表明患者反应受损。酒精导致的敏感性衰减随着偏心度的增加而增加（P = 0.046），与子午线无关（P = 0.068），从偏心度3度时的平均0.8dB增加到27度时的1.84dB。
