Tiv M, Puyraveau M, Mineur L, Calais G, Maingon P, Bardet E, Mercier M, Bosset J-F
EA3181, Besançon University Hospital, University of Franche-Comté, 2 place Saint-Jacques, 25030 Besançon cedex, France.
Cancer Radiother. 2010 Oct;14(6-7):530-4. doi: 10.1016/j.canrad.2010.06.017. Epub 2010 Aug 24.
Few studies have evaluated the quality of life (QoL) of patients with rectal cancer. This report describes the quality of life of French patients who entered the 22921 EORTC trial that investigated the role and place of chemotherapy (CT) added to preoperative radiotherapy (preop-RT).
Patients without recurrences were evaluated with EORTC QLQ-C30 and QLQ-CR38 questionnaires, after a median time of 4.6 years from randomisation.
All the scores of QLQ-C30 functions were high, from 78 up to 88, with those of global health quality of life scale (GHQL) status being 73. The mean scores of symptoms were low except for diarrhoea. For QLQ-CR38, the mean scores for "body image" and "future perspective" were high at 79.6 and 69.7 respectively. The scores for "sexual functioning" and "enjoyment" were low. Men had more sexual problems than females (62.5 vs 25 mean scores respectively). Chemotherapy was associated with more diarrhoea complaints, lower "role", lower "social functioning" and lower global health quality of life scale.
The overall quality of life of patients with rectal cancer is quite good 4.6 years after the beginning preoperative treatments. However, adding chemotherapy to preoperative radiotherapy has a negative effect on diarrhoea complaints and some quality of life dimensions.
很少有研究评估直肠癌患者的生活质量（QoL）。本报告描述了参加22921欧洲癌症研究与治疗组织（EORTC）试验的法国患者的生活质量，该试验调查了术前放疗（preop-RT）联合化疗（CT）的作用和地位。
随机分组后中位时间4.6年，对无复发的患者使用EORTC QLQ-C30和QLQ-CR38问卷进行评估。
QLQ-C30功能量表的所有得分都很高，从78到88，其中全球健康生活质量量表（GHQL）评分为73。除腹泻外，症状的平均得分较低。对于QLQ-CR38，“身体形象”和“未来展望”的平均得分较高，分别为79.6和69.7。“性功能”和“享受”的得分较低。男性的性问题比女性更多（平均得分分别为62.5和25）。化疗与更多的腹泻主诉、更低的“角色”、更低的“社会功能”以及更低的全球健康生活质量量表得分相关。
直肠癌患者在术前治疗开始4.6年后的总体生活质量相当好。然而，术前放疗联合化疗对腹泻主诉和一些生活质量维度有负面影响。
