Department of Clinical Microbiology, Isparta State Hospital, Isparta, Turkey.
Biol Trace Elem Res. 2011 Sep;142(3):447-55. doi: 10.1007/s12011-010-8826-7. Epub 2010 Aug 27.
The aim of the present study was to measure the changes in serum selenium, zinc, and copper in patients being treated for rheumatoid arthritis. Thirty-two patients and 52 healthy controls were included in the study. The copper level was higher and those of selenium and zinc were lower in the patients relative to controls. Treatment with methotrexate elevated the zinc levels, but not zinc and selenium. Treatments with salazopyrin, corticosteroids, chloroquine, and non-steroidal anti-inflammatory drugs did not change the levels of any of the elements studied. The decrease in zinc and selenium levels and elevation in copper levels observed in the patients probably resulted from the defense response of organism and are mediated by inflammatory-like substances.
本研究的目的是测定类风湿关节炎患者治疗过程中血清硒、锌、铜的变化。共纳入 32 例患者和 52 例健康对照者。与对照组相比，患者的铜水平较高，而硒和锌水平较低。甲氨蝶呤治疗可使锌水平升高，但对硒和锌无影响。柳氮磺胺吡啶、皮质类固醇、氯喹和非甾体抗炎药治疗均未改变所研究元素的水平。患者中观察到的锌和硒水平降低以及铜水平升高可能是由于机体的防御反应所致，并由类似炎症的物质介导。
