Ramírez-Marrero Farah A, Smit Ellen, De La Torre-Feliciano Taína, Pérez-Irizarry Javier, Miranda Sandra, Cruz Maritza, Figueroa-Vallés Nayda R, Crespo Carlos J, Nazario Cruz M
University of Puerto Rico School of Medicine, San Juan.
P R Health Sci J. 2010 Sep;29(3):256-64.
The risk of cancer among Hispanics with Acquired Immune Deficiency Syndrome (AIDS) in the United States and Puerto Rico (PR) has not been well described. The purpose of this study was to determine the risk of AIDS related and non-AIDS related cancers among Hispanics with AIDS in PR.
A probabilistic record linkage of the PR AIDS Surveillance Program and PR Central Cancer Registry databases was conducted. AIDS cases were grouped according to year of AIDS onset and antiretroviral therapy availability: 1987-1989 (limited availability), 1990-1995 (mono and dual therapy), and 1996-2003 (highly active antiretroviral therapy: HAART). Cancer risk was described using the standardized incidence ratios (SIR).
A total of 612 cancers were identified after 3 months of AIDS diagnosis: 409 (66.7%) AIDS related and 203 (33.1%) non-AIDS related. Although a decreasing trend in the risk of AIDS and non-AIDS related cancers was observed, the risk for both remained higher in the AIDS group compared to the general population in PR. Non-AIDS related cancers with higher risk during the HAART availability were: oropharyngeal, anal, liver, larynx, eye and orbit, Hodgkin lymphoma, and vaginal.
Hispanics with AIDS in PR consistently showed a greater risk of AIDS and non-AIDS related cancers compared to the general population in PR and that has not changed over time.
在美国和波多黎各（PR），患有获得性免疫缺陷综合征（AIDS）的西班牙裔人群患癌症的风险尚未得到充分描述。本研究的目的是确定PR地区患有AIDS的西班牙裔人群中与AIDS相关和非AIDS相关癌症的风险。
对PR艾滋病监测项目和PR中央癌症登记数据库进行概率记录链接。AIDS病例根据AIDS发病年份和抗逆转录病毒治疗的可获得性进行分组：1987 - 1989年（可获得性有限）、1990 - 1995年（单一和双重疗法）以及1996 - 2003年（高效抗逆转录病毒治疗：HAART）。使用标准化发病比（SIR）描述癌症风险。
在AIDS诊断3个月后共确诊612例癌症：409例（66.7%）与AIDS相关，203例（33.1%）与非AIDS相关。尽管观察到与AIDS相关和非AIDS相关癌症的风险呈下降趋势，但与PR地区的普通人群相比，AIDS组中这两种癌症的风险仍然更高。在HAART可获得期间风险较高的非AIDS相关癌症包括：口咽癌、肛门癌、肝癌、喉癌、眼和眼眶癌、霍奇金淋巴瘤以及阴道癌。
与PR地区的普通人群相比，PR地区患有AIDS的西班牙裔人群患与AIDS相关和非AIDS相关癌症的风险一直更高，且这一情况并未随时间变化。
