University of St Andrews, Scottish Universities Physics Alliance, School of Physics and Astronomy, North Haugh, Fife, United Kingdom.
J Biomed Opt. 2010 Jul-Aug;15(4):041503. doi: 10.1117/1.3475958.
The biomedical sciences have benefited immensely from photonics technologies in the last 50 years. This includes the application of minute forces that enable the trapping and manipulation of cells and single molecules. In terms of the area of biophotonics, optical manipulation has made a seminal contribution to our understanding of the dynamics of single molecules and the microrheology of cells. Here we present a review of optical manipulation, emphasizing its impact on the areas of single-molecule studies and single-cell biology, and indicating some of the key experiments in the fields.
在过去的 50 年中，生物医学科学极大地受益于光子学技术。这包括应用微小的力来实现细胞和单分子的捕获和操纵。就生物光子学领域而言，光学操纵对我们理解单分子动力学和细胞的微流变学做出了开创性的贡献。本文综述了光学操纵，强调了它对单分子研究和单细胞生物学领域的影响，并指出了这些领域中的一些关键实验。
