Siatkin S P, Frolov V A
Patol Fiziol Eksp Ter. 1990 Jul-Aug(4):13-5.
The direct effect of temperature on the structural integrity of lysosomes was studied. Destruction of these particles was minimum in hypothermia but increased sharply in hyperthermia. A studied concentrated lysosome fraction proved to be heterogeneous in thermoresistance. The lysosome membranes started melting at 12.5 degrees C and melted completely at 38.5 degrees C. The results of the study show that the surrounding temperature may produce a direct damaging effect on the lysosomes, and support the assumption that the lysosomes play an important role as one of the key factors of the molecular mechanisms of the formation of a pathological condition in generalized hypo- and hyperthermia.
研究了温度对溶酶体结构完整性的直接影响。在低温条件下，这些颗粒的破坏最小，但在高温条件下急剧增加。研究发现浓缩的溶酶体部分在耐热性方面具有异质性。溶酶体膜在12.5摄氏度时开始融化，并在38.5摄氏度时完全融化。研究结果表明，周围温度可能对溶酶体产生直接破坏作用，并支持以下假设：溶酶体作为全身低温和高温情况下病理状态形成分子机制的关键因素之一，发挥着重要作用。
