School of Physical Education and Sports, Anadolu University, Eskişehir, Turkey.
J Strength Cond Res. 2010 Sep;24(9):2491-7. doi: 10.1519/JSC.0b013e3181ddb111.
The purposes of this study were (a) to determine whether acute resistance exercise training (RET) induces oxidative stress, (b) to determine whether chronic RET decreases oxidative stress level at rest condition in previously untrained men, and (c) also to investigate how the RET intensity influences the training-induced oxidative stress response. Sixteen young men who did not have RET experience in the past were randomly divided in 2 groups. Hypertrophy-intensity group (n = 9) performed 3 sets of 12 repetitions at an intensity corresponding to 70% of 1 repetition maximum (1RM), whereas strength-intensity group (n = 7) performed 3 sets of 6 repetitions at an intensity corresponding to 85% of 1RM. Resistance exercise training involved 6 exercises, and it was performed 3 times a week on nonconsecutive days for 6 weeks. Blood samples were obtained just before (pre-RET) and immediately after RET (post-RET) on the first day of the first week, on the last day of the fourth and sixth weeks. The results indicated that malondialdehyde (MDA) significantly decreased (p < 0.05) in both groups immediately after RET; however, there was no significant acute alteration in glutathione (GSH) level in both groups (p > 0.05). After 6 weeks of training, pre-RET values of MDA significantly decreased and pre-RET values of GSH significantly increased in both hypertrophy- and strength-intensity groups (p < 0.05). These alterations occurred independently of training intensity. This study indicated that hypertrophy- and strength-intensity whole-body RET performed regularly for 6 weeks, decreased MDA concentration and increased GSH level in healthy young men. Results suggest that chronic RET has protective effects against oxidative stress similar to aerobic exercises and that these effects seem to be independent of the training intensity.
(a) 确定急性抗阻运动训练（RET）是否会引起氧化应激；(b) 确定慢性 RET 是否会降低未经训练的男性在静息状态下的氧化应激水平；(c) 还研究 RET 强度如何影响训练引起的氧化应激反应。16 名过去没有 RET 经验的年轻男性被随机分为 2 组。肥大强度组（n = 9）以相当于 1 次最大重复次数（1RM）的 70%的强度进行 3 组 12 次重复，而力量强度组（n = 7）以相当于 1RM 的 85%的强度进行 3 组 6 次重复。抗阻运动训练涉及 6 项运动，每周进行 3 次，非连续进行 6 周。在第 1 周的第 1 天，第 4 周和第 6 周的最后 1 天，在进行 RET 之前（RET 前）和 RET 后即刻（RET 后）采集血液样本。结果表明，两组的丙二醛（MDA）在 RET 后即刻均显著降低（p < 0.05）；然而，两组的谷胱甘肽（GSH）水平均无显著急性变化（p > 0.05）。经过 6 周的训练，肥大强度组和力量强度组的 MDA 预 RET 值显著降低，GSH 预 RET 值显著升高（p < 0.05）。这些变化与训练强度无关。本研究表明，健康年轻男性定期进行 6 周的全身肥大和力量强度 RET，可降低 MDA 浓度并增加 GSH 水平。结果表明，慢性 RET 对氧化应激具有保护作用，类似于有氧运动，并且这些作用似乎与训练强度无关。
