Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan.
J Biomed Sci. 2010 Aug 24;17 Suppl 1(Suppl 1):S20. doi: 10.1186/1423-0127-17-S1-S20.
Taurine, a sulfur-containing beta-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardiac and skeletal muscles. Meanwhile, taurine deficiency leads various pathologies, including dilated cardiomyopathy, in cat and fox. However, the essential role of taurine depletion on pathogenesis has not been fully clarified. To address the physiological role of taurine in mammalian tissues, taurine transporter-(TauT-) knockout models were recently generated. TauTKO mice exhibited loss of body weight, abnormal cardiac function and the reduced exercise capacity with tissue taurine depletion. In this chapter, we summarize pathological profile and histological feature of heart and skeletal muscle in TauTKO mice.
牛磺酸是一种含硫的β-氨基酸，在心脏和骨骼肌中含量很高。牛磺酸具有多种生物学作用，如心肌和骨骼肌中的离子运动、钙处理和细胞保护。同时，牛磺酸缺乏会导致各种病理，包括猫和狐狸的扩张型心肌病。然而，牛磺酸耗竭对发病机制的重要作用尚未完全阐明。为了阐明牛磺酸在哺乳动物组织中的生理作用，最近生成了牛磺酸转运体（TauT）敲除模型。TauTKO 小鼠表现出体重减轻、心脏功能异常和运动能力下降，同时伴有组织牛磺酸耗竭。在这一章中，我们总结了 TauTKO 小鼠心脏和骨骼肌的病理特征和组织学特征。
