Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA.
J Nat Prod. 2010 Sep 24;73(9):1606-9. doi: 10.1021/np100467d.
A Phormidium spp. collection from Key West, Florida, afforded caylobolide B (1), an analogue of the known macrolactone caylobolide A, previously isolated from a Lyngbya majuscula collection from the Bahamas. The planar structure of 1 was determined using NMR and MS experiments. The relative configuration for subunits C7-C9 and C25-C29 was assigned using Kishi's Universal NMR Database. Caylobolide B (1) displayed cytotoxic activity against HT29 colorectal adenocarcinoma and HeLa cervical carcinoma cells with IC(50) values of 4.5 and 12.2 μM, respectively.
从佛罗里达州基韦斯特采集的束丝藻属（Phormidium spp.）样品中分离得到了 caylobolide B（1），这是一种先前从巴哈马的 Lyngbya majuscula 样品中分离得到的大环内酯 caylobolide A 的类似物。通过 NMR 和 MS 实验确定了 1 的平面结构。通过 Kishi 的通用 NMR 数据库确定了亚基 C7-C9 和 C25-C29 的相对构型。Caylobolide B（1）对 HT29 结肠直肠腺癌细胞和 HeLa 宫颈癌细胞表现出细胞毒性，IC50 值分别为 4.5 和 12.2 μM。
