完成 1 年和 2 年多药治疗（MDT）后的反应。
Reactions following completion of 1 and 2 year multidrug therapy (MDT).
机构信息
Leonard Wood Memorial Center for Leprosy Research, Cebu City, Philippines.
出版信息
Am J Trop Med Hyg. 2010 Sep;83(3):637-44. doi: 10.4269/ajtmh.2010.09-0586.
We evaluated the incidence, severity, and duration of reactional states in 139 multibacillary (MB) leprosy patients in the first 2 years after the completion of the 1 year regimen of multidrug therapy (MDT) currently recommended by the World Health Organization (WHO) and compared those findings with 295 MB leprosy patients treated with the same regimen previously recommended for 2 years. During the first year after the completion of 1 year MDT, patients experienced 1 or more reactional states 27% of the time, the vast majority being lepra type 1 reactions (reversal reactions, RR), whereas patients who received 2 year MDT experienced a reactional state during that time period only 8% of the time (P < 0.001). Furthermore, during the first year after the completion of therapy, and during the first 2 years, both the number of reactional states and reversal reactions were significantly (P < or = 0.004) more frequent, severe, of longer duration, and more commonly associated with neuritis.
我们评估了 139 例多菌型（MB）麻风病患者在完成世卫组织（WHO）目前推荐的 1 年多药治疗（MDT）方案后的头 2 年内反应状态的发生率、严重程度和持续时间，并将这些发现与 295 例接受相同方案治疗的 MB 麻风病患者进行了比较，这些患者之前接受了 2 年的治疗。在完成 1 年 MDT 后的第一年，患者有 1 次或多次反应状态的时间占 27%，绝大多数是麻风 1 型反应（逆转反应，RR），而接受 2 年 MDT 的患者在那段时间只有 8%的时间（P < 0.001）发生反应状态。此外，在治疗完成后的第一年和前两年，反应状态和逆转反应的数量、严重程度、持续时间以及更常与神经炎相关的情况都明显（P < or = 0.004）更为频繁。
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