Hashimoto K, Prince C, Kato I, Ito M, Tazawa T, Pelachyk J M, Mikhail G R
Wane State University, Department of Dermatology, Detroit, MI 48201.
J Cutan Pathol. 1989 Feb;16(1):19-30. doi: 10.1111/j.1600-0560.1989.tb00004.x.
A hair matrix tumor showing an unusual tumor cell arrangement was found at the base of a solitary trichoepithelioma. Coexisting with solid epithelial islands and immature hair follicle-like stroma resembling the Verocay bodies of neurilemmoma or "ripplemarks" on waves were found. In other areas myxomatous degeneration of the stroma changed the rippling into a cribriform pattern. In some parts of the tumor there was a dense melanin pigment associated with MEL5 stained melanocytes. S-100 and CD1 (OKT6) antigen stains demonstrated Langerhans cells scattered in the parenchyma and less frequently in the stroma. The majority of tumor cells were considered immature pilar cortical cells because of the following: 1. HKN-6 was strongly positive; 2. a large number of melanocytes were associated with tumor cells in some foci; 3. ultrastructurally immature tumor cells, which had electron-dense tonofilaments and many desmosomes, were transformed without production of trichohyalin granules into semikeratinized cells which showed nuclear degeneration and loss of electron density in tonofilaments. This tumor, however, has not attained the degree of differentiation observed in trichoblastoma (1) another example of an immature cortical cell tumor. Squamous eddy-like or horn pearl-like foci of incomplete keratinization and large keratin-filled cysts were also present within the immature parenchyma, indicating that some immature cells were differentiating toward non-cortical cells, as found in the outer sheath. We would like to designate this tumor "rippled pattern trichomatricoma", a new entity.
在一个孤立性毛发上皮瘤的底部发现了一个具有异常肿瘤细胞排列的毛母质瘤。可见与实性上皮岛并存，且存在类似于神经鞘瘤的Verocay小体或波浪状“波纹”的未成熟毛囊样间质。在其他区域，间质的黏液样变性将波纹状改变为筛状模式。在肿瘤的某些部位，有与MEL5染色的黑素细胞相关的致密黑色素沉着。S-100和CD1（OKT6）抗原染色显示朗格汉斯细胞散在于实质中，较少见于间质。大多数肿瘤细胞被认为是未成熟的毛皮质细胞，原因如下：1. HKN-6呈强阳性；2. 在一些病灶中，大量黑素细胞与肿瘤细胞相关；3. 超微结构上，未成熟的肿瘤细胞具有电子致密的张力丝和许多桥粒，可转变为半角化细胞，而不产生毛透明颗粒，这些半角化细胞显示核变性和张力丝电子密度丧失。然而，该肿瘤尚未达到成毛细胞瘤（1）（另一种未成熟皮质细胞瘤的例子）中观察到的分化程度。在未成熟的实质内也存在鳞状涡状或角珠样不完全角化灶以及大的充满角蛋白的囊肿，这表明一些未成熟细胞正在向外鞘中发现的非皮质细胞方向分化。我们将此肿瘤命名为“波纹状毛母质瘤”，这是一种新的实体。
