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[氙气研究的当前进展。对麻醉和重症医学的重要性]

[Current developments in xenon research. Importance for anesthesia and intensive care medicine].

作者信息

Brücken A, Coburn M, Rex S, Rossaint R, Fries M

机构信息

Klinik für Anästhesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52074 Aachen.

出版信息

Anaesthesist. 2010 Oct;59(10):883-95. doi: 10.1007/s00101-010-1787-6.

Abstract

The noble gas xenon exerts favorable anesthetic properties along with remarkable hemodynamic stability in healthy patients undergoing elective surgery. It represents the nearly ideal anesthetic and provides safe and well controllable anesthesia although the exact mechanism by which xenon produces anesthesia remains to be elucidated. In addition xenon offers organ protective properties for vital organs including the brain, heart and kidneys which seem to be synergistic when used in combination with therapeutic hypothermia. As the high cost of xenon will probably preclude its wider use as a routine anesthetic, data from extensive tests in large numbers of high risk patients is needed to confirm its possible superiority in this setting.

摘要

惰性气体氙在接受择期手术的健康患者中具有良好的麻醉特性以及显著的血流动力学稳定性。它堪称近乎理想的麻醉剂,能提供安全且易于控制的麻醉效果,尽管氙产生麻醉的确切机制仍有待阐明。此外,氙对包括脑、心脏和肾脏在内的重要器官具有器官保护特性,与治疗性低温联合使用时,这些特性似乎具有协同作用。由于氙的高成本可能会妨碍其作为常规麻醉剂的更广泛应用,因此需要大量高危患者的广泛测试数据来证实其在此情况下可能具有的优势。

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